The colon is the terminal part of the GIT which has gained as a potential site for delivery of various novel therapeutic drugs i.e. peptides. Colon targeted drug delivery system (CDDS) is an Promising tool for treatment of inflammatory bowel diseases such as ulcerative colitis, crohn's disease, colon cancer, amobebiasis by both systemic and topical delivery of dug. This article review a detailed study about disease of colon, diagnosis of diseases of colon, anatomy of colon, factors affecting drug absorption and different approaches of colon including some current approaches like Pulsinicap system, Port system, Probiotic approach, Chronotropic system, Colal-pred system, Enterion capsule Technology Muliparticulate system and some past studies on colon drug delivery with evaluation method for site specific drug delivery to colon.

Objective: The objective of the work is to formulate nizatidine mucoadhesive matrix tablets which will significantly improve the bioavailability of drugs under the condition of prolonged use of drugs and reduce the total dosage of administered drug and reduce the side effect.Method: Matrix tablet was prepared by direct compression of polymer such as HPMC K4M, carbopol-934p, and ethyl cellulose alone and in combination.Result: After analysis of different evaluation parameter and drug release, F9 batch was selected as promising formulation for delivery of nizatidine as a mucoadhesive matrix tablet with 94.18% drug release at the 12 th h. Conclusion:It was observed that the combination of both polymers in equal concentration gives the best drug release and sustains the drug release for 12 h. Among the other batches, F9 batch was selected as an optimized batch because the pre-and post-compression parameter results are satisfactory.

Objective: The objective of this study was to develop an in situ ophthalmic gel of an anti-infective drug, moxifloxacin (MOX) hydrochloride (HCL), for sustained ocular delivery for the treatment of bacterial infections of the eye. Method: In the present work the in situ gelling systems were prepared by ion exchange method with the help of various concentrations of gelling agent gelrite (0.08 g, 0.1 g and 0.12 g) and sodium alginate (0.6 g, 0.8 g and 1 g) as viscosity enhancer were added in the formulation; 9 formulations were prepared according to 32 factorial designs and evaluated. The responses were analyzed for the analysis of variance using Design-Expert version 10 software. Statistical models were generated for each response parameter. Results: Optimized formulation batch F7 (0.12% gelrite and 0.6% sodium alginate) was liquid before addition of simulated tear fluid (STF) and underwent rapid gelation on addition of STF and had given 84.05% cumulative drug release; the formulation was found to be clear, having good in situ gelling capacity, good antibacterial efficacy, having drug content 99.75%; optimized formulation was sterile and showed sustained drug release over 8 h period as compared to marketed eye drop. Conclusions: From the above results, we can concluded that 32 full factorial design and statistical models can be successfully used to optimize the formulations, and it was concluded that the trial batch F7 (0.12% gelrite and 0.6% sodium alginate) is the best formula (percentage cumulative drug release over 84.05%) and it is possible to formulate in situ ophthalmic gels of MOX HCL using gelrite in combination with sodium alginate for the treatment of various bacterial infections of the eyes.

The objective of the work is to recognize the recent advancements in the modern health care and drug delivery systems. The article describes few recent developments in technology like artificial intelligence, personalized medicines, customized medicines, 3D printing, bioelectronic devices and tele pharmacy, which have the potential to augment health care and drug delivery in coming times. Personalized medication ensures precise health care as per the individual genetic makeup of the patients. The 3D printing technology enables to deliver tailor made solutions to fulfil individual patient requirements. Bioelectronic medicines and devices are new technology where the patient wears a device and its electrical signal cures certain ailments. Tele pharmacy ensures that the technological advances of telecommunications are also passed on to the patient health care sector. Moreover, it can be said that all these modern developments ensure that the quality of life improves and there comes a better control on the health care costs. Keywords: artificial intelligence, personalized medicines, customized medicines, 3D printing, bioelectronic devices and tele pharmacy