Background: Seizure is a common neurological disorder in the pediatric age group. Objective: Neonates with seizure have decreased in serum calcium, magnesium, sodium, potassium, and glucose if compared to neonates without seizure. Methodology: This comparative cross-sectional study was carried out in the Department of Biochemistry at Mymensingh Medical Collage, Mymensingh, Bangladesh in cooperation with the Department of Pediatric of Mymensingh Medical Collage & Hospital, Mymensingh, Bangladesh from July 2005 to June 2006. Neonates were included in the study. Subjects were divided into two groups designated as group I as control group and group II cases. From each subject at least 2 ml of blood were collected from femoral vein and was collected serum for biochemical analysis. Result: A total of 60 neonates were included in the study. Subjects were divided into two groups-group-I control- (n=20) and group II cases-(n=40). The concentration of serum calcium, magnesium, sodium, potassium, and glucose yielded 7.33 ±0.79, 5.79 ±1.10; 2.18 ± 0.23,1.61 ± 0.25; 134.82 ±3.03, 133.68±8.57; 4.80 ±0.56,5.89 ±2.02; 66.33 ± 8.23, 62.25± 7.96 in group I and group II respectively. Conclusion: Significant decreases of serum calcium, magnesium and significant increase of serum potassium in neonates with seizure are found in this study. The change in serum sodium and glucose are not significant. Journal of Current and Advance Medical Research, January 2021;8(1):25-29

A cross sectional study of 129 type 2 diabetic patients attending out patient department of Community Based Medical College Hospital was done with an aim to evaluate their metabolic control. Of the total cases, 88 (68.2%) were male and 41 (31.8%) were female. Blood glucose and lipid levels were measured by following the standard laboratory methods. The study subjects had relatively poor glycemic control. Fasting serum glucose was 7.45±2.71 (mmol/l, mean±SD); Male-7.04±2.36 and Female 8.33±3.20, p=ns'. Mean (±SD) of total cholesterol and triglyceride of the female subjects were significantly higher compared to the male counterpart (p=0.01 for both). About 71% and 78.0% female subjects had triglyceride and HDLc abnormality compared to 63.3% and 61.4% respectively in their male counterpart. Fasting glucose level showed significant positive correlation with triglyceride among total and male study subjects (p=0.003 for both). In case of total cholesterol significant positive association was among total and female subjects (p=0.005 and 0.007 respectively).  The data concluded that (i) relatively large number of diabetic patients were having dyslipidemia of either component or in combination; and (ii) attention needs to be paid to address this issue of dyslipidemia and to avoid or at least delay the coronary artery and atherosclerotic complications of these subjects. CBMJ 2014 January: Vol. 03 No. 01 P: 20-24

Abstract:Background: Rotavirus infects almost all children by the age of five. More than 180,000 annual deaths due to rotavirus, occurs in Bangladesh. Aims: This study aimed to determine the incidence of rotavirus infection in children by a modified polyacrylamide gel electrophoresis (PAGE) in stool samples. Materials and Methods: In this descriptive type cross sectional study, a total of 400 stool samples were examined for the presence of rotavirus by a modified PAGE analysis of viral genome. Stool culture was done for common enteric pathogens. The study was carried out from November 2012 to July 2013 in the department of Microbiology, Mymensingh Medical College, Mymensingh. Results: PAGE results were found in 365 of 400 (91%) specimens. Maximum incidence of rotavirus infection was seen in age group of 6 months -24 months (67.25%). All 151 rotavirus positive cases did not show infection with bacterial pathogens. Conclusion: The modified PAGE technique for the detection of viral RNA was found to be rapid, simple, reliable and less expensive technique.

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Liver cirrhosis is an end stage condition of liver disease and the leading cause of death for both men and women all over the world. It causes death due to acute or chronic gastrointestinal blood loss & multi organ failure. The aim of the study is to evaluate the serum Copper, Zinc and Iron levels in patients with liver cirrhosis. A total 120 subjects were included in this study. Among them, 60 diagnosed decompensated liver cirrhosis patients denoted as case group (n=60) and 60 were normal healthy individuals denoted as control group (n=60), both the case and control groups were male because liver cirrhosis occurs rarely female in Bangladesh. The subjects were briefed and written consents were taken. Under all aseptic precaution 5 ml of venous blood was collected from median cubital vein, analysis was carried out in the Department of Biochemistry, Mymensingh Medical College, Mymensingh, over a period of one year from July 2015 to June 2016. All statistical analysis was performed by SPSS windows package, version 20. Significance of the difference between two groups were evaluated by using student's unpaired 't' test. All the values were expressed as mean ± SD and P value 0.05 was taken as the level of significance. After careful evaluation, in the present study we found significant increase in the serum Copper levels and significant decreases in the serum Zinc and Iron levels in liver cirrhosis patients when compared with that of control group. It can be concluded that to overcome fatal consequences of decompensated liver cirrhosis patients we should avoid high Copper containing food provides Zinc and Iron supplementation as well as blood transfusion may be beneficial. CBMJ 2019 July: Vol. 08 No. 02 P: 10-16