Carpal tunnel is the narrow space which is present between smaller bones of hand and an important ligament of hand which is called transverse carpal ligament. Compression of median nerve occurs commonly at wrist which results in Carpal Tunnel Syndrome (CTS). Objective: To compare effectiveness of median nerve mobilization with and without transverse carpal ligament stretching in patients with carpal tunnel syndrome. Methods: In this study, 34 patients were randomly assigned into one of two groups, each with 17 individuals. For two weeks, group B received a combination therapy strategy of Neurodynamics and transverse carpal ligament stretching, while group A only received neurodynamics. After two weeks, there was an improvement in functioning and pain. The DASH questioner and VAS were filled at baseline. The current RCT was conducted at the Akhtar Saeed Trust Hospital in Lahore. SPSS was used to conduct the analysis. Results: In the present study of 34 patients independent sample t test was applied as the mean difference was less in group B, which used a combination treatment method of transverse carpal ligament stretching and neurodynamics, compared to group A, which used only neurodynamics. The p value is less than 0.05, indicating that the results were significant. In comparison to group A, results of group B in which combined treatment approach was applied found to be more substantial and superior. Conclusions: Group B, which included both neurodynamics and transverse carpal ligament stretching, was shown to be more effective than group A, which solely used neurodynamics.