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Arsenic contamination in groundwater in the Padma-Meghna fluvial plains in Bangladesh and Ganga-Brahmaputra fluvial plains in India and its consequences to the human health have been described as one of the world's largest natural groundwater catastrophes to the manhood. In India, seven states namely: Jharkhand, Bihar, Uttar Pradesh, and West Bengal in the flood plain of the Ganga River, Manipur and Assam in the flood plain of the Brahamaputra and Imphal rivers and Rajnandgaon community in Chhattisgarh state have so far been reported pretentious by Arsenic contamination in groundwater exceeding the permissible limit of 10 μg/L. People in these affected states have frequently been exposed to drinking Arsenic contaminated hand tube-well water. Arsenic groundwater contamination has far-reaching consequences including its consumption through food chain which are in the form of social disorders, health hazards and socioeconomic dissolution besides its sprawling with movement, and exploitation of groundwater. Arsenic contamination is implicit to be of geogenic origin released from soil under conditions promisingto dissolution of Arsenic from solid phase on soil grains to liquid phase in water, and percolation of fertilizer residues might have played a modifying role in its further exaggeration. Despite a number of remedial and protective measures, the spread of Arsenic contamination in groundwater continued to grow and more new areas were also added to the list of contaminated areas. The problem resolving issues, thus, seemed to be incomplete and insufficient, which need to be supported by strategic scientific support.