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We report the synthesis, structure, and reactivity of [Fe(T1Et4iPrIP)(OTf)2] [1; T1Et4iPrIP = tris(1-ethyl-4-isopropylimidazolyl)phosphine]. Compound 1 reacts reversibly with nitric oxide to afford [Fe(T1Et4iPrIP)(NO)(THF)(OTf)](OTf) (2), which is the first example of a 6-coordinate {FeNO}(7) S = 3/2 complex containing a linear Fe-N-O group. 2 exhibits the highest ν(NO) for compounds in this class. Density functional theory studies reveal an enhanced degree of β-electron transfer from π*(NO) to the Fe d orbitals accounting for the large stretching frequency.

Diospyrin, a bis-naphthoquinone derivative,has been identified as a biologically active principle present in the bark extract of Diospyros montana Roxb. which inhibited the in vivo growth of Ehrlich Ascites Carcinoma (E.A. C.), in Swiss A mice. A series of in vitro and in vivo investigations have been carried Out to confirm this observation. OH 0 Diospyrin furnished betulin and lupeol, and a bis-naphthoquinone derivative, diospyrin. Bio-assay did not show any inhibitory action of betulin and lupeol towards E.A.C. in vivo, while diospyrin exhibited significant activity. Hence, diospyrin was isolated from the stem bark and purified following the reported method (5) and some experiments, comprising both in vitro and in vivo actions, were carried out to study its biological activity against E.A.C. in mice. In vitro studies were related to (a) the action of diospyrin on isolated E.A.C. cells and (b) the respiratory behaviour of the isolated E.A.C. cells in presence of diospyrin. In vivo tests were conducted to study (a) the increase in longevity and inhibiton of tumour growth by treatment with diospyrin and (b) the changes in the haematological parameters of E.A.C.bearing mice after treatment with diospyrin. Ph. D. Dissertation (in part) of B. H.