Table of contentsP001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP effluxR. M. Bateman, M. D. Sharpe, J. E. Jagger, C. G. EllisP002 - Lower serum immunoglobulin G2 level does not predispose to severe flu.J. Solé-Violán, M. López-Rodríguez, E. Herrera-Ramos, J. Ruíz-Hernández, L. Borderías, J. Horcajada, N. González-Quevedo, O. Rajas, M. Briones, F. Rodríguez de Castro, C. Rodríguez GallegoP003 - Brain protective effects of intravenous immunoglobulin through inhibition of complement activation and apoptosis in a rat model of sepsisF. Esen, G. Orhun, P. Ergin Ozcan, E. Senturk, C. Ugur Yilmaz, N. Orhan, N. Arican, M. Kaya, M. Kucukerden, M. Giris, U. Akcan, S. Bilgic Gazioglu, E. TuzunP004 - Adenosine a1 receptor dysfunction is associated with leukopenia: A possible mechanism for sepsis-induced leukopeniaR. Riff, O. Naamani, A. DouvdevaniP005 - Analysis of neutrophil by hyper spectral imaging - A preliminary reportR. Takegawa, H. Yoshida, T. Hirose, N. Yamamoto, H. Hagiya, M. Ojima, Y. Akeda, O. Tasaki, K. Tomono, T. ShimazuP006 - Chemiluminescent intensity assessed by eaa predicts the incidence of postoperative infectious complications following gastrointestinal surgeryS. Ono, T. Kubo, S. Suda, T. Ueno, T. IkedaP007 - Serial change of c1 inhibitor in patients with sepsis – A prospective observational studyT. Hirose, H. Ogura, H. Takahashi, M. Ojima, J. Kang, Y. Nakamura, T. Kojima, T. ShimazuP008 - Comparison of bacteremia and sepsis on sepsis related biomarkersT. Ikeda, S. Suda, Y. Izutani, T. Ueno, S. OnoP009 - The changes of procalcitonin levels in critical patients with abdominal septic shock during blood purificationT. Taniguchi, M. OP010 - Validation of a new sensitive point of care device for rapid measurement of procalcitoninC. Dinter, J. Lotz, B. Eilers, C. Wissmann, R. LottP011 - Infection biomarkers in primary care patients with acute respiratory tract infections – Comparison of procalcitonin and C-reactive proteinM. M. Meili, P. S. SchuetzP012 - Do we need a lower procalcitonin cut off?H. Hawa, M. Sharshir, M. Aburageila, N. SalahuddinP013 - The predictive role of C-reactive protein and procalcitonin biomarkers in central nervous system infections with extensively drug resistant bacteriaV. Chantziara, S. Georgiou, A. Tsimogianni, P. Alexandropoulos, A. Vassi, F. Lagiou, M. Valta, G. Micha, E. Chinou, G. MichaloudisP014 - Changes in endotoxin activity assay and procalcitonin levels after direct hemoperfusion with polymyxin-b immobilized fiberA. Kodaira, T. Ikeda, S. Ono, T. Ueno, S. Suda, Y. Izutani, H. ImaizumiP015 - Diagnostic usefullness of combination biomarkers on ICU admissionM. V. De la Torre-Prados, A. Garcia-De la Torre, A. Enguix-Armada, A. Puerto-Morlan, V. Perez-Valero, A. Garcia-AlcantaraP016 - Platelet function analysis utilising the PFA-100 does not predict infection, bacteraemia, sepsis or outcome in critically ill patientsN. Bolton, J. Dudziak, S. Bonney, A. Tridente, P. NeeP017 - Extracellular histone H3 levels are in...

Background: Acute lung injury (ALI) is associated with significant mortality and morbidity. C-reactive protein (CRP) level a marker of systematic inflammation is widely-used in numerous clinical conditions, however little is known about the characteristics of CRP levels in patients with ARDS and acute lung injury (ALI).The aim of this work was to examine the plasma level of C-reactive protein (CRP) in patients with acute lung injury (ALI) and its relationship with prognosis, outcome, and severity of illness.Patients and methods: The study was carried out on 100 consecutive patients, who were admitted to the Critical Care Medicine Departments in Alexandria Main University Hospital. Inclusion criteria were patients were aged >18 years who had one or more of the acute lung injury (ALI) predisposing conditions. Patients who developed ALI based on standard definition according to the American-European consensus conference were examined for C-reactive protein levels measured in serum (mg/dl) collected within 48 h after fulfillment of criteria.Results: CRP levels were the highest in patients with complete recovery ranging between 190 and 233 mg/dl with a mean of 211.5 ± 30.406 mg/dl, modest in patients who recovered with residual complications ranging between 107 and 120 with a mean of 111.33 ± 7.506 mg/dl, and lowest in patients who died ranging between 35 and 106 with a mean of 79.55 ± 24.007 mg/dl. Higher CRP levels were significantly associated with better survival (P = 0.000). There was an inverse relationship between CRP levels and duration of mechanical ventilation while ICU stay increased as the CRP levels increased. The relationships between CRP levels and both mechanical ventilation days and ICU stay were statistically non significant (P = 0.710 and 0.801 respectively). CRP levels were lower in patients who developed multiorgan dysfunction syndrome (MODS) with a mean of 76.6 ± 28.778 mg/dl compared to a mean of 111.43 ± 59.332 mg/dl in patients who didn't develop MODS, this relationship was not statistically significant (P = 0.060).Conclusions: Although CRP has widely been considered to be a marker of systemic inflammation, our findings show that higher levels of CRP are associated with decreased mortality, organ failure, and need for mechanical ventilation among patients with ALI.

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peak Cr: 1.8 ± 0.9 vs 2.0 ± 1.3, P=0.26; duration: 6 ± 7 vs 6 ± 9 days, P=0.82) was not predictive. Recurrent AKI patients had higher mortality (inpatient: 21% vs 9%, P=0.02; 12-month: 44% vs 22%, P=0.01), persistent renal dysfunction (discharge Cr: 1.3 ± 1.1 vs 0.9 ± 0.4, P<0.0001), and longer lengths of stay (SICU: 13 ± 15 vs 9 ± 11 days, P=0.04; hospital: 37 ± 31 vs 23 ± 17 days, P<0.0001). Conclusions: Recurrent AKI is common among critically ill surgical patients who recover from an index episode. It is associated with increased mortality, impaired renal function and greater resource utilization versus non-recurrence. Index AKI on admission is the only apparent risk factor for recurrence, although further study is warranted to better define causes of recurrence.