Background: Computer vision syndrome (CVS) can be described as ocular-related symptoms that result from prolonged exposure and use of computers, smartphones, tablets, and other devices with digital displays. The main objective of this study was to investigate the prevalence of CVS among school-age children, the associated signs, risk factors, and the association between the disease before and during the COVID-19 pandemic in the Jazan region of Saudi Arabia. Methods: The study employed a descriptive cross-sectional research design. The targeted population was school-going children aged 6 to 18 in the Jazan region in the Southwest of Saudi Arabia. A sample of 440 participants was selected to represent the population under study. Data were collected using self-administered questionnaires. Sociodemographic characteristics were recorded, such as age, gender, education level, parents’ education, occupation, frequency, and intensity of eye symptoms if present. Results: Most of the participants were adolescents between 16 and 18 and at a high-school education level. According to the total symptoms score, the CVS prevalence was 35.4%. Prevalence of CVS significantly affects age, gender, and school level (p < 0.05 for all). A similar significant association was reported between the symptoms experienced before and during COVID-19 and the CVS (p < 0.05). Conclusion: A total of 407 adolescents aged 16–18 responded to the questionnaire (response rate of 92.5%; 407 out of 440). The study estimated the prevalence of CVS among school-going children in Jazan to be low. The main signs associated with CVS included headache, tearing, itchiness, blurred vision, eye redness, eye pain, and dryness. The attitude of children toward their health condition during the COVID-19 pandemic and the prevalence of CVS have a significant relationship.

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