BACKGROUND: COVID-19 is a respiratory tract infection caused by the coronavirus. Some patients with severe symptoms require hospital treatment needing oxygen support. The COVID-19 condition affects the hemodynamic status of the patient. AIM: This study aimed to analyze the effect of murottal surah Ar-Rahman therapy on the hemodynamic status of COVID-19 patients in A. Yani Islamic Hospital Surabaya. METHODS: This research design was a quasi-experiment with pre-test–post-test one group design without a control group. The population was the confirmed positive patient for COVID-19 who were treated in the Mina Room of A. Yani Islamic Hospital Surabaya from November 2020 to January 2021 with a total of 63 patients. The sample was 55 patients which were taken by purposive sampling. The variables in this study were the hemodynamic status, including blood pressure, respiration rate, heart rate, and oxygen saturation that were given murottal therapy Surah Ar-Rahman. Data were analyzed using Paired t-test and those that were not normally distributed by sign-test. RESULTS: The results of this study found that there were differences in the pre-post variables of systolic blood pressure (p = 0.000), heart rate (p = 0.000), respiration rate (p = 0.000), and oxygen saturation (p = 0.000). There was no difference in the diastolic blood pressure variable (p = 0.263). CONCLUSIONS: This study concluded that the Surah Ar-Rahman therapy murottal can be used and effective to improve hemodynamic status in conjunction with therapy from the medical team. This therapy is also very easy to use anywhere.