Background/objective Early identification of mortality risk in perforated peptic ulcer (PPU) patients is important for triage and risk stratification. This study aimed to compare clinical and laboratory factors and three scoring systems to predict mortality in PPU patients. Methods Retrospective data on PPU patients at M. Djamil Hospital who underwent emergency laparotomy repair surgery were collected from December 2018 to May 2021. The data included demographics, clinical characteristics, and three scoring systems. Data analysis used bivariate, multivariate, and ROC analysis. Results A total 72 patients were included and mortality rate was 52.8%. Bivariate analysis showed a significant association between age (p = 0.029), onset of illness (p = 0.001), alteration of consciousness (p = <0.001), respiratory rate (p = 0.04), duration of surgery (p = 0.040), preoperative shock (p = 0.049), preoperative creatinine (p = <0.001), Boey's scores (p = 0.002), ASA (p = 0.001), and qSOFA scores (p = <0.001) with mortality in PPU patients. From multivariate analysis, the strongest clinical factors associated with mortality were alteration of consciousness (p = <0.001) and preoperative creatinine (p = 0.001). Receiver Operating Characteristic (ROC) analysis showed the area under the curve (AUC) of Boey's Score 0.73, ASA classification 0.69, qSOFA score 0.77, alteration of consciousness 0.74, and preoperative creatinine 0.78. Conclusion Preoperative creatinine and altered consciousness had the strongest association with mortality in PPU patients. The qSOFA score predicted mortality better than Boey's score and ASA classification. Preoperative creatinine was the best single predictor of mortality.

Background/objective Tropical chronic pancreatitis (TCP) is common in developing countries and is defined as a juvenile form of chronic calcific non-alcoholic pancreatitis. Pseudocysts occur in 20–40% of chronic pancreatitis. TCP with pseudocyst has not been reported yet, so we represent this rare case to broaden the horizons regarding pancreatitis. Case presentation A 16-year-old woman suffered a painful lump in the upper abdomen. She came from a low-income family and frequently consumed cassava. There was intolerance of glucose in which admission blood sugar level of the patient increased by 179 mg/dl. An abdominal CT scan showed a mass around the pancreas, 20 cm in diameter, and located in retro-gastric. There were multiple ductal calculi along the major pancreatic duct with the largest stone was 3 cm in the pancreatic head. Longitudinal pancreaticojejunostomy (Partington-Rochelle procedure) has been performed and histopathological results appropriate with a pancreatic pseudocyst. Clinical discussion TCP with a giant pseudocyst is an interesting case report that has not been reported yet. This case met the clinical characteristics of TCP, such as young women, malnourished, history of cassava consumption, abdominal pain, and intolerance of glucose. A surgical intervention provides a satisfactory result to the patient. Conclusion Tropical chronic pancreatitis is a rare case. A pseudocyst adds the uniqueness of this case that has never been reported before. Appropriate management can provide satisfactory results and improve the quality of life for patients.

BACKGROUND: The progression of hepatitis B is affected by the activity of T lymphocytes. Activation of T lymphocytes requires a primary signal originating from the presentation of antigen by HLA molecules to T cell receptors. HLA-DQB1 gene polymorphisms can affect the ability of HLA to bind and present viral antigens to T cells, thus affecting T cell activation and potentially associated with the progression of chronic hepatitis B. AIM: We aimed to investigate the polymorphisms of the HLA-DQB1 gene and its influence on chronic hepatitis B progression of chronic hepatitis B patients in Indonesia. METHODS: This cross-sectional research studied chronic hepatitis B patients at the Internal Medicine Department, Arifin Ahmad Hospital, Pekanbaru, from January 2018 to December 2018. Subjects were grouped into three categories: (1) Inactive chronic hepatitis B, (2) active chronic hepatitis B, and (3) end stage liver disease (ESLD) which consisted of patients with liver cirrhosis and hepatocellular carcinoma. Examination of the HLA-DQB1 gene polymorphism was performed with the SSP-PCR method and sequenced to verify the PCR results. Analysis results of p < 0.05 were considered statistically significant. RESULTS: The most common allele in patients with chronic hepatitis B was the HLA-DQB1 0301. The HLA-DQB1 0301 allele found primarily in the inactive chronic hepatitis B group. The DQB1 0501 allele found to be more abundant in patients with active chronic hepatitis B. The HLA DQB1 0502 allele only found in patients with chronic hepatitis B with ESLD. CONCLUSIONS: The HLA-DQB1 gene polymorphism is associated with the progression of chronic hepatitis B in chronic hepatitis B patients in Indonesia.