Background: Talent management and its effective practices ensures an organization fills vital positions for future leaders and positions that support its core competencies, show commitment to nurses, gave a raise to their self-efficacy which lead to increase nurses' engagement and decrease their turnover, and had positive impact on organizational effectiveness. The study aimed to assess talent management and its relation to staff nurses' self-efficacy and organizational effectiveness. Design: Descriptive correlational design was applied. Setting: the study was conducted at the eleven critical care units in Benha University Hospital. Sample: Convenience sample of (227) staff nurses were taken from the previously mentioned setting. Data collection tools: Three tools were used for data collection; talent management questionnaire, general self-efficacy scale -Turkish form and organizational effectiveness questionnaire. Results: More than two fifth of staff nurses (44.5%) had moderate perception level of talent management. While, more than half of studied staff nurses (52%) perceived their self-efficacy as moderate. Moreover, more than two thirds of studied staff nurses (68.7%) perceived moderate level of organizational effectiveness. Conclusion: There was a highly statistical significant positive correlation between overall score of talent management, self-efficacy, and organizational effectiveness among staff nurses. The study recommended: Developing strategies which help in development and retention of talented nurses. Providing a supportive wok environment that promotes trust, cohesion and commitment among staff nurses which reflect positively on the effectiveness inside the organization.