Platelet-rich fibrin (PRF), a second-generation platelet concentrate, was developed for the purpose of overcoming the limitations of Platelet-rich plasma (PRP). PRF can produce a higher cumulative release of growth factors than PRP. Also, this release is slow and prolonged, making it ideal for tissue regeneration and growth stimulation. This study was conducted to evaluate the efficacy of fluid PRF either alone or combined with needling versus PRP in the treatment of atrophic acne scars. A comparative study including 30 patients with atrophic acne scars who were divided into two equal groups. Group I included 15 patients in which the left side of the face was treated with intradermal injection of PRP while the right side was treated with combined needling with PRP. Group II included15 patients in which the left side of the face was treated with intradermal injection of fluid PRF while the right side was treated with combined needling with fluid PRF. All patients received four sessions with 3 weeks interval. The acne scars significantly improved in both sides of face in both groups. According to quartile grading scale and patient satisfaction; the therapeutic response was significantly higher in PRF group than PRP either alone or combined with needling. The combination with needling increases efficacy of PRF and PRP. Fluid PRF is highly effective, safe and simple procedure that can be used instead of PRP in the treatment of acne scars.

Background: There are many forms of scars that can result from inflammatory acne. It has a negative impact on the patient's personal and professional relationships. Acne scars are caused by the aberrant creation or breakdown of collagen that happens during healing processes. Atrophic scarring is the consequence in the majority of instances (80-90%) of collagen degradation at the dermal level. Hypertrophic or keloid scars are rarer manifestations of an enhanced collagen synthesis. Platelet rich fibrin (PRF) was introduced into the acne scar care picture after platelet-derived growth factor (PDGF) was proven to stimulate wound healing, angiogenesis, and tissue remodelling. Minimally invasive platelet-rich plasma methods provide the advantage of a fast recovery time and low cost.Objective: To examine the potential role of platelet rich fibrin in the treatment of post-acne scars. Methods: The databases were searched for articles published in English in 3 data bases [PubMed -Google scholar-Science direct] and Boolean operators (and, or, not) had been used such as [Platelet Rich Fibrin and Post Acne Sars OR PRF] and in peer-reviewed articles between 2009 and 2021. Documents in a language apart from English were excluded as sources for interpretation was not found. Papers apart from main scientific studies were excluded: documents unavailable as total written text, conversation, conference abstract papers and dissertations. Conclusion: Cell migration and proliferation are more efficient when fibrin is rich in platelets. When compared to platelet rich plasma, the fibrin matrix favours a slow and steady release of growth factors over time.