Warts are viral cutaneous infections caused by human papilloma virus (HPV), presented by verrucous growth over the skin surface. 1 Its histopathological features entail keratinocyte hypercornification. 2 Around two-thirds of lesions can be spontaneously healed within 2 years without therapy. 3 The immune response is considered to play a crucial role in HPV clearance. It depends on intact cellular immunity including natural killer (NK) cell and cytotoxic T cells. It has been clarified that T-helper (Th) 1 cytokines (interleukin (IL)-2, interferon-γ, and tumor necrosis factor-a) and IL-17 are involved in HPV clearance. Defective cell-mediated immunity or the imbalance