Objective: Chenopodium album L is the species of the genus chenopodium. The Greek name Chenopodium means goosefoot. The plant is native to Asia and Europe. The analysis of the constituents of the Iraqi plant was performed using gas chromatography and high-performance liquid chromatography techniques.Methods: Thin-layer chromatography (TLC) and high-performance TLC chromatographic techniques were used for the detection and isolation of the active constituent found in the plant. Spectral analysis such as nuclear magnetic resonance (NMR) and UV was used to confirm the chemical structure of the compound isolated. Results:Astragalin was isolated and identified by comparison with standard kaempferol 3-O-β-glucoside (astragalin) which was detected as the major glycoside in the polar fraction of the plant. Further, identification of the compound was performed by 1 H-NMR spectroscopy. Conclusion:Astragalin is the major flavonoid glycoside found in the plant.

Thiazolidinone, a saturated form of thiazole with a carbonyl group on fourth carbon, has been considered as a magic moiety (wonder nucleus) that possesses almost all types of biological activities. A new series of 4-thiazolidinones bearing ketoprofen moiety had been designed, then synthesized by reacting Schiff-base with chloroacetic acid and sodium acetate in ethanol according to Baldwin rules for ring closure and finally evaluated as a potent cyclooxygenase-2 (COX-2) inhibitors. Characterization and identification of the synthesized compounds were established by the determination of 1 H-NMR spectra, 13 C-NMR, FT-IR spectroscopy, and physical properties. These newly synthesized compounds have been evaluated in vivo for their anti-inflammatory efficiency and In silico selectivity toward COX-2 through molecular docking by using GOLD suite v.5.6.2. All the tested compounds via molecular docking showed anti-inflammatory activity and some of them have significant activity when compared with diclofenac, and ketoprofen as referenced drugs because of having hydrogen bonding interaction toward the key amino acids within COX isozymes Tyr355, and Met522, and all these results were compatible with the study of in vivo acute anti-inflammatory activities for tested compounds. Also, ADME studies had been accomplished to predict which compounds are a candidate to be taken orally, absorption sites, bioavailabilities, topological polar surface area(TPSA), and also drug-likeness. The ADME results reported that all the synthesized compounds can be absorbed from GIT. The objective of this work is to synthesize and initial pharmacological assessment of new derivatives of ketoprofen by studying their interactions with COX-1 and COX-2 by docking and to determine some relationships between their structures and biological activity. Incorporating of the 4-thiazolidinone nucleus into ketoprofen moiety to increase the selectivity toward COX-2. Comparing the In silico results with In vivo results by using egg white to induce acute inflammation. The antiinflammatory assessment was done for six final compounds.