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SUMMARYSera from 39 patients with SLE, 20 patients with cerebrovascular disease with no evidetice of SLE, atid 20 normal controls were tested for antibodies to cardiolipin (CL). brain total upper (UPG) and lower phase (LPG)glycolipids, myelin basic protein (MBP), myeliti, and single strand DNA (ssDNA) by ELISA. Binding to the glycolipids and MBP was negative or negligible in all the groups, but significant binding was observed against CL. myelin and ssDNA in some ofthc SLE patients. Many sera from SLE patients with cerebral disorders and high CL binding also demonstrated high binding to myelin. These sera also labelled cell surfaee antigens on neonatal mouse neurons and astrocytes by immunofluorescence in tissue eulture. A correlation was found to exist between anti-CL and antimyelin antibodies in SLE patients with cerebral lesions, but not between anti-ssDNA and anti-CL antibodies. As much as 80-90% of the specific aetivity of these antibodies could be absorbed out by the relevant antigens but only partially by the other antigens. In the control groups binding was low and no specific absorption could be demonstrated.

To mitigate the impact of the COVID-19 pandemic, several vaccines have been developed and administered to the public since 2021. A spectrum of cutaneous reactions has been reported among some of the vaccinated individuals. In this case series, we describe three cases of pityriasis rosea and pityriasis rosea-like eruption that manifested after COVID-19 vaccinations, which might suggest the vaccines as a possible trigger.

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