The survival outcome in BC survivors is likely to have some correlation with exercise; long-term physical activity levels are important for BC prognosis and are associated

Objective: Lower limb amputation is common in war combat and armed conflict as well as in traumatic settings and presents a challenge for health care providers. The incorporation of advanced technologies, particularly virtual reality, presents an opportunity to address the main consequences of amputation, principally balance and gait. The aim of this study was to investigate the additional effect of virtual reality with a traditional rehabilitation exercise program on balance and gait in unilateral, traumatic lower limb amputees. Materials and Methods: Thirty-two traumatic lower limb amputees, fulfilling a postfitting rehabilitation program at least 6 months ago, were recruited and randomly assigned into two identically sized groups; group C (control group) experiencing the traditional exercise program and group VR (virtual reality group) experiencing an addition of a virtual reality training. The intervention was conducted over 6 weeks at a rate of three sessions per week. Outcome measures assessed before and after 6 weeks were the Berg Balance Scale (BBS), Timed Up and Go (TUG) test, Dynamic Gait Index (DGI), and 6-minute walk test (6 MWT). Results: Both interventions induced improvement in all measured parameters (P < 0.05); however, virtual reality demonstrated significant superior effects only on the balance markers, TUG test, DGI, and BBS (P < 0.05), but not on the 6 MWT (P > 0.05). Conclusion: Virtual reality is a promising, amusing, and safe intervention for addressing balance and gait in unilateral, traumatic lower limb amputees.

Introduction. Hypertrophic scars and keloids are physically and mentally disturbing, and can cause pain and itching. Various treatment is utilized to diminish or counteract scarring. The purpose of this study was to compare the effect of silicone gel, Contractubex gel, and corticosteroid phonophoresis for post-burn hypertrophic scars. Methods. A prospective, single-blind, randomized, controlled study with pretest-posttest design was performed; 45 patients aged 20-45 years with hypertrophic scars, 2-4 months post thermal burn were involved. They were randomly assigned to 3 groups: group A (15 patients, 8 males and 7 females) received phonophoresis with silicone gel, group B (15 patients, 8 males and 7 females) received phonophoresis with Contractubex gel, and group C (15 patients, 9 males and 6 females) received corticosteroid phonophoresis. All treatment interventions were applied at the frequency of 3 sessions/week for 24 weeks. The participants were recruited from the Kasr El-Ani hospital outpatient clinic to be treated in the outpatient clinic, Faculty of Physical Therapy, Cairo University. Results. outcome measures were taken with the modified Vancouver Scar Scale (VSS) before the treatment, and 12 and 24 weeks after the intervention. The comparison among the 3 groups revealed a highly significant decrease in modified VSS total score in group A compared with group B and group C (p < 0.01), as well as in group B compared with group C (p < 0.001). Conclusions. Silicone gel phonophoresis is a more effective method for post-burn hypertrophic scar management than Contractubex gel phonophoresis or corticosteroid phonophoresis.

Long noncoding RNAs (lncRNAs) play regulatory role in cellular processes and their aberrant expression may drive cancer progression. Here we report the function of a lncRNA PAINT (prostate cancer associated intergenic noncoding transcript) in promoting prostate cancer (PCa) progression. Upregulation of PAINT was noted in advanced stage and metastatic PCa. Inhibition of PAINT decreased cell proliferation, S‐phase progression, increased expression of apoptotic markers, and improved sensitivity to docetaxel and Aurora kinase inhibitor VX‐680. Inhibition of PAINT decreased cell migration and reduced expression of Slug and Vimentin. Ectopic expression of PAINT suppressed E‐cadherin, increased S‐phase progression and cell migration. PAINT expression in PCa cells induced larger colony formation, increased tumor growth and higher expression of mesenchymal markers. Transcriptome analysis followed by qRT‐PCR validation showed differentially expressed genes involved in epithelial mesenchymal transition (EMT), apoptosis and drug resistance in PAINT‐expressing cells. Our study establishes an oncogenic function of PAINT in PCa.

Long non-coding RNAs (lncRNAs) play regulatory roles in cellular processes and their aberrant expression may drive cancer progression. Here we report the function of a lncRNA PAINT (Prostate Cancer Associated Intergenic Non-Coding Transcript) in promoting prostate cancer (PCa) progression. Upregulation of PAINT was noted in advanced stage and metastatic PCa. Inhibition of PAINT decreased cell proliferation, S-phase progression, increased expression of apoptotic markers, and improved sensitivity to docetaxel and Aurora kinase inhibitor VX-680. Inhibition of PAINT decreased cell migration and reduced expression of Slug and Vimentin. Ectopic expression of PAINT suppressed E-cadherin, increased S-phase progression and cell migration. PAINT expression in PCa cells induced larger colony formation and higher expression of mesenchymal markers. Transcriptome analysis followed by qRT-PCR validation showed differentially expressed genes involved in epithelial mesenchymal transition (EMT), apoptosis and drug resistance in PAINT-expressing cells. Our study establishes an oncogenic function of PAINT in PCa.