RESUMO:A anomalia de Pelger-Huët é um distúrbio hereditário raro caracterizado pela falha na segmentação do núcleo dos granulócitos, especialmente dos neutrófilos. Os neutrófilos geralmente apresentam núcleos hipossegmentados ou redondos, embora a condensação da cromatina e o desenvolvimento citoplasmático assemelham-se a de granulócitos maduros normais. A hipossegmentação do núcleo afeta 30 a 70% das células e mimetiza o estado de imaturidade celular, semelhante ao observado hematologicamente no desvio à esquerda. A anomalia de Pelger-Huët foi relatada em humanos, coelhos, cães e gatos, sendo esses relatos escassos e poucos casos foram descritos em animais e, no estado do Espírito Santo ainda não havia sido relatada. O reconhecimento dessa anomalia é importante para prevenir uma associação incorreta com doenças que produzem um desvio à esquerda. Relatamos um caso da anomalia de Pelger-Huët em uma cadela da raça Cocker Spaniel com 9 anos de idade. Palavras-chave: cão; desvio a esquerda; hematologia; hipossegmentação de neutrófilos PELGER-HUËT ANOMALY -CASE REPORTABSTRACT: Pelger-Huët anomaly is a rare hereditary disorder characterized by failure of the nucleus of granulocytes, especially neutrophils, to undergo normal maturation to the segmented form. Affected neutrophils have unsegmented or round nuclei, but chromatin condensation and cytoplasmic development resemble that of normal mature granulocytes. This nuclear hyposegmentation results in an apparent left shift in neutrophils. Affected animals have a normal total leukocyte count, but the major form of neutrophils is at the band stage, with bands comprising 30-70% of total cells. The Pelger-Huët anomaly has been reported in humans, rabbits, dogs, and cats. Few cases had been described in animals and, in the state of Espiríto Santo not yet had been reported. Recognition of this syndrome is important to prevent an incorrect association with diseases that produce a left shift. A case report of the Pelger-Huët anomaly is presented in a 9 years old Cocker Spaniel female dog.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.