In the present study, antiimplantation activity of methanolic extract of Cordia dichotoma Lam. bark was evaluated. The methanolic extract of bark of Cordia dichotoma showed significant antiimplantation activity. Pretreatment with methanolic extract showed significant inhibition of number of implant site at a dose of 100-mg/kg-body weight. There was no change in ovulation; hence the antiimplantation activity observed in the present study with Cordia dichotoma bark can be attributed largely to its inhibition of number of implants. However, an investigation of the antiimplantation activity showed no increase in body weight or uterine content of blood glucose, cholesterol and triglyceride levels when compared with control group.

The effectiveness of any herbal medication is dependent on the delivery of effective level of the therapeutically active compounds. Herbosomes are recently introduced herbal formulations that are better absorbed and as a result produce better bioavailability and actions than the conventional botanical extracts. Herbal excipients are non-toxic and compatible they have a major role to play in pharmaceutical formulation. Herbal medicines have been widely used all over the world since ancient times and have been recognized by physicians and patients for their better therapeutic value as they have fewer adverse effects as compared to modern medicines. However, phytotherapeutics needs a scientific approach to deliver the components in a sustained manner to increase patient's compliance and avoid repeated administration. This can be achieved by designing novel drug delivery systems for herbal constituents. Over the last decade, herbal and Ayurvedic drugs has become a subject of world importance, with both medicinal and economical implications. There are number of traditional herbal remedies for the treatment and management of diseases related to teeth, gum and oral hygiene. The aim of the present study is to present overall view of the current strategies adopted for the formulation and application of traditional herbal remedies. This review article summarizes the current data on the effect of natural products like Acacia catechu, Aloe vera, Chamomile, Azadirachata indica, and Glycyrriza glabra on management of various periodontal diseases together with their biological activities.

The antibacterial study revealed that the isolated marine soil actinomycetes by crowded plate method and was identified by MIDI Advance technology (gas chromatographic) method and Thus, the microbes were identified according to their fatty acid sequences. The actinomycetes species were identified as Streptomyces rimosus, Streptomyces fradiae, and Streptomyces griseoflavus and the antibacterial assay was carried out by well diffusion method. Out of these only Streptomyces rimosus having high antimicrobial potential against Gram positive as well as Gram negative bacteria. In Gram positive Streptomyces aureus exhibits higher sensitivity followed by Bacillus subtilis where as gram negative bacteria E.Coli was extremely sensitive to the metabolites followed by Pseudomonas aeruginosa.

Ethyl-2-amino-4-chloro-6-(2, 4, 6 trichloro phenyl amino) pyrimidine-5-carboxylate and ethyl-2-amino 4-chloro-1, 3-dimethyl-6-(phenyl amino)-1,2,3,4 tetrahydro pyrimidine-5-carboxylate derivatives were synthesized through Cyclocondensation and Michel type of addition reaction with the aromatic anilines, guanidine and benzamidines. Synthesized novel derivatives were confirmed by elemental analysis viz., IR, 1HNMR and Mass spectroscopy.These novel derivatives have been screened for Antibacterial, Antifungal and Antiinflammatory activity.

The present study showed that the ethanolic extracts from the bark of Acacia concurrens exhibited a strong antioxidant activity. Among all the fractions from ethanolic extracts of bark, the EtOAc soluble fraction exhibited the best antioxidant performance. Furthermore, the amounts of total phenolic compound were determined from the ethanolic extracts. Therefore, Acacia concurrens could be considered as a potential source of natural antioxidant.