Histopathological Study of Guided Lung Biopsies IntroductionSmall lung biopsies are the most common and the first lung sample obtained when a radiologic abnormality is detected and tissue diagnosis is required. [1] Both CT guided FNA and core needle biopsies have been documented to be effective for diagnosis of peripheral lung lesions including non neoplastic and neoplastic lesions. [2] CT guided biopsy may have an advantage over CT guided FNA for obtaining more tissue to perform Immunohistochemistry and/or molecular study. Image guided biopsies are less susceptible to false-negative or false positive diagnosis when compared with FNACs. [2] Lung cancer is the commonest cancer and the biggest cause of cancer mortality worldwide. Every year lung cancer causes more than 1.6 million deaths, more than breast, colon, and prostate cancers combined. [3] Lung is also one of the most common metastatic sites of many primary cancers. [2] Tissue is often required to differentiate primary from metastasis, benign lesions from malignant lesions and further classify a primary lung cancer for treatment.However, the vast majorities of patients present with either locally advanced or metastatic disease and do not proceed to surgical resection so the diagnosis of lung cancer is confirmed using small biopsies/cytology. [4] Among malignancies, Non small cell lung carcinoma is the most common lung cancer, accounting for about 85%