Study DesignWe performed a multicentric, randomized, comparative clinical trial. Eligible patients were randomly assigned to receive 150 mg of Tolperisone thrice daily or 8 mg of Thiocolchicoside twice daily for 7 days.PurposeTo assess the efficacy and tolerability of Tolperisone in comparison with Thiocolchicoside in the treatment of acute low back pain with spasm of spinal muscles.Overview of LiteratureNo head on clinical trial of Tolperisone with Thiocolchicoside is available and so this study is done.MethodsThe assessment of muscle spasm was made by measuring the finger-to-floor distance (FFD), articular excursion in degrees on performing Lasegue's maneuver and modified Schober's test. Assessment of pain on movement and spontaneous pain (pain at rest) of the lumbar spine was made with the help of visual analogue scale score.ResultsThe improvement in articular excursion on Lasegue's maneuver was significantly greater on day 3 (p = 0.017) and day 7 (p = 0.0001) with Tolperisone as compared to Thiocolchicoside. The reduction in FFD score was greater on day 7 (p = 0.0001) with Tolperisone. However there was no significant difference in improvement in Schober's test score on day 3 (p = 0.664) and day 7 (p = 0.192). The improvement in pain score at rest and on movement was significantly greater with Tolperisone (p = 0.0001).ConclusionsTolperisone is an effective and well tolerated option for treatment of patients with skeletal muscle spasm associated with pain.

Magnetic susceptibilities have been measured by the Gouy method for several tungsten oxides oE the series WO,. At 297.5"K. the susceptibility per unit volume is found t o increase n~o~~otonically from -0.65 X lope to +0.46 X 10-o as x in WO, decreases from 3 to 2. Results are interpretable in terms of a defect structure in which 3x oxygen atoms have been removed from a host WO, lattice leaving 2(3x) rlectrons iii the conduction band of the host. Quantitative agreement with a Pauli-Peierls calcrrlation is surprisingly good. The model may be applicable to other non-stoichiometric oxides for which "mixetl-oxidation-state" structures have been postulated.

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