Aus dem Aldehyd (I) werden mit Phenylhydrazin (II) das Hydrazon (III) und hieraus durch Umsetzung mit Diazoniumsalzen (IV) die Formazane (V) hergestellt.
Fifteen new formazans were synthesized by the condensation of the 4-nitrophenylhydrazone of 3-nitro-anisaldehyde with the appropriate phenyldiazonium salts. Their in vivo an!iviral activity was evaluated against Ranikhet disease virus (RDV) in chick embryos. Out of the compounds screened, (8) showed maximum (62.5 %) protection against RDV. The structure activity relationship has further been studied and is discussed.
1-[4'-carboxyphenyl]-3-[3-nitro4methoxyphenyl]-S-[4-nitrophenyl]formazan
Synthese e w e r nenen Fonnmne Pls potentielle antivlrnle AgentienFunfzehn neue Formazane wurden durch Kondensation des 4-Nitrophenylhydrazons des 3-Nitroanisaldehydes mit Phenyldiazoniumsalzen synthetisiert und ihre in-vivo antivirale Wirksamkeit gegen Ranikhet-disease-Virus (RDV) in Huhnerembryonen gepriift. Unter diesen Verbindungen, wurde die starkste signifikante Schutzwirkung (bis zu 62.5 %) nit 1-(4'-Carboxyphenyl]-3-[3'-nitro-4'-methoxyphenyl]-5-[4'-nitrophenyl] formazan (8) erzielt. Die Struktur-Aktivitatsbeziehungen werden studiert und diskutiert. The biological utility of formazans for staining tissues and visualization of reducing enzymes in normal neoplastic are known for a long time. Their antibacterial') activity has come to light when Kuhn undJerchel screened them against various strains of bacteria. Libman et al." reported the antiviral activity of p-aminophenyl-2,5-diphenyltetrazolium chloride against influenza A and Nigg mouse pneumonitic virus. Recently Misra et al.') have synthesized a number of formazans and their tetrazolium salts and observed some of them to be active against RDV. In view of these observations of a broad spectrum of antiviral properties associated with formazan derivatives, it was thought of interest to synthesize some new formazan derivatives as potential antiviral agents. 0365-6233/81/1212-0991 I 0Z.Mm
Aus dem p‐Nitrophenylhydrazon (III) des durch Nitrierung von (I) erhaltenen Nitroanisaldehyds (II) werden mit den Diazoniumsalzen (IV) die Formazane (V) hergestellt, die z.Tl. antivirale Aktivität besitzen.
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