Hospital (MCHH), a small urban hospital in Kumasi, Ghana, were enrolled in the study. Oral consent was obtained and the study was approved by Komfo Anokye Teaching Hospital and the Ethics Committee of the University of Chicago. The time each woman remained in the hospital determined if she was assigned to the early discharge group (<8 hours) or normal discharge group (>8 hours). Information on the pregnancy, delivery and the health of the newborn was recorded at birth. Additional health information was obtained at 1, 6, 10, and 14 weeks of age. Findings: The early and normal discharge groups included 123 and 133 women, respectively. The median post-delivery hospital stay at MCHH was 8.9 hours. For all infants in the study, there was a nearly 100 percent completion of immunizations and no infant deaths at 14 weeks. The mean infant weight gain in the first week of life was 0.17 kg for the early discharge group and 0.25 kg for the normal discharge group (Two-Sample T-Test, P¼0.1). Early discharge was not significantly associated with rhinorrhea, cough, diarrhea, fast breathing, vomiting, poor feeding, fever, or seizure. Interpretation: We conclude that for low-risk pregnancies with uncomplicated deliveries, early discharge does not adversely affect infant health at MCHH. We attribute this outcome to an effective triage system between MCHH and a much larger neighboring tertiary care center. These results suggest that development of maternal and child health triaging systems can promote efficiency and cost-reduction in resource limited settings.