No abstract

No abstract

No abstract

No abstract

The monitoring and controlling of vascular endothelial growth factor (VEGF) are very important in the treatment of certain cancers and age-related macular degeneration. Herein, a microfluidic based method was introduced to generate low-cost flexible VEGF graphene biosensors, demonstrating tunable thickness of graphene composites different from the conventional graphene composites in chemical detection. After alternating the surface wetting ability, a PDMS based microfluidic system duplicated from a silicon mold was used to introduce, confine and pattern the graphene films. This microfluidic induced graphene biosensor modified with the anti-VEGF antibody from Mayo Clinic is capable of detecting VEGF as low as 1 pg/mL. A promising technique is presented to develop the low-cost and high-performance biosensors for the VEGF detection.