Introduction: Jaundice is a clinical condition that is often present in pediatric practice and constitutes one of the major issues within the neonatal period. It occurs in both the physiological and pathological processes in newborns. Study aimed to evaluate the predictive value of umbilical cord bilirubin in identifying term newborns with ABO/Rh incompatibility for subsequent hyperbilirubinemia in 1st week of life. Material and Methods: 150 Term newborns with the gestational age of 36-40 weeks with the APGAR score of over 7 at the first minute and 10 at the fifth minute of life were taken. Baby with significant illness or major congenital malformation were excluded from the study. Results: 150 newborns were divided into hyperbilirubinemia and non-hyperbilirubinemia groups. Mean total Cord Bilirubin is more in Rh incompatibility (4.23) when compared to ABO incompatibility (3.86). Mother's blood group has statistical signification with Hyperbilirubinemia and Non-hyperbilirubinemia, but it was not seen in the baby's blood group. The mean Hb of Hyperbilirubinemia and Non-hyperbilirubinemia is 15.6 ± 0.7 and 14.2± 2 gm/dL respectively, and the difference between them was statistically significant. The mean Cord Bilirubin between babies with Hyperbilirubinemia and Non-hyperbilirubinemia was 4 ± 0.5 and 2.3 ± 0.3 mg/dL respectively, and the difference between them was statistically significant. The relationship between total Cord Bilirubin and SBR was statistically significant Conclusion: The total cord bilirubin in healthy term newborns provides the prediction for neonatal jaundice in 1st week of life. The cutoff value is 3.25 with 96% of specificity and 96% sensitivity.