The effect of Gymnema montanum leaves on alloxaninduced hyperlipidemia was studied in male Wistar rats. Ethanolic extract of G. montanum leaves was administered orally and different doses of the extract on blood glucose, serum and tissue lipids, hexokinase, glucose-6-phosphatase, thiobarbituric acid-reactive substances (TBARS), hydroperoxides, and glutathione in alloxan-induced diabetic rats were studied. G. montanum leaf extract (GLEt) at doses of 50, 100, 200 mg/kg body weight for 3 weeks suppressed the elevated blood glucose and lipid levels in diabetic rats. GLEt at 200 mg/kg body weight was found to be comparable to glibenclamide, a reference drug. These data indicate that G. montanum represents an effective antihyperglycemic and antihyperlipidemic adjunct for the treatment of diabetes and a potential source of discovery of new orally active agent for future therapy.Keywords Alloxan Diabetes; Blood Glucose; Carbohydrate Enzymes; Gymnema montanum; Lipids Experimental diabetes in animals has provided considerable insight into the physiologic and biochemical derangements of the diabetic state. Many of the derangements have been characterized in hyperglycemic animals. Significant changes in lipid metabolism and structure also occur in diabetes [1]. In these cases, the structural changes are clearly oxidative in nature and
The effects of Gymnema montanum, an endangered plant used in the ancient period of India, on blood glucose, plasma insulin, and carbohydrate metabolic enzymes were studied in alloxan diabetic rats. Administration of alcoholic extract of G. montanum leaves (50, 100, 200 mg/kg body weight) to alloxan diabetic rats for 3 weeks reduced the blood glucose level. Administration of G. montanum leaf extract (GLEt) at 200 mg/kg body weight significantly decreased the blood glucose levels and significantly increased the plasma insulin levels. This clearly shows the antidiabetic efficacy of GLEt, which was better than that of glibenclamide.
Introduction: Jaundice is a clinical condition that is often present in pediatric practice and constitutes one of the major issues within the neonatal period. It occurs in both the physiological and pathological processes in newborns. Study aimed to evaluate the predictive value of umbilical cord bilirubin in identifying term newborns with ABO/Rh incompatibility for subsequent hyperbilirubinemia in 1st week of life. Material and Methods: 150 Term newborns with the gestational age of 36-40 weeks with the APGAR score of over 7 at the first minute and 10 at the fifth minute of life were taken. Baby with significant illness or major congenital malformation were excluded from the study. Results: 150 newborns were divided into hyperbilirubinemia and non-hyperbilirubinemia groups. Mean total Cord Bilirubin is more in Rh incompatibility (4.23) when compared to ABO incompatibility (3.86). Mother's blood group has statistical signification with Hyperbilirubinemia and Non-hyperbilirubinemia, but it was not seen in the baby's blood group. The mean Hb of Hyperbilirubinemia and Non-hyperbilirubinemia is 15.6 ± 0.7 and 14.2± 2 gm/dL respectively, and the difference between them was statistically significant. The mean Cord Bilirubin between babies with Hyperbilirubinemia and Non-hyperbilirubinemia was 4 ± 0.5 and 2.3 ± 0.3 mg/dL respectively, and the difference between them was statistically significant. The relationship between total Cord Bilirubin and SBR was statistically significant Conclusion: The total cord bilirubin in healthy term newborns provides the prediction for neonatal jaundice in 1st week of life. The cutoff value is 3.25 with 96% of specificity and 96% sensitivity.
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