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Syntheses of unusual pyrrole alkaloids Penicinoline E, Marinamide and Methyl marinamide were successfully achieved in two steps from easily accessible starting materials with excellent overall yields 70–97 %. The Suzuki‐Miyaura coupling followed by dearomatization represents the key step in the synthesis of title compounds. The structure of Penicinoline E was unequivocally confirmed by single X‐ray analysis. The antiplasmodial activity of alkaloids was evaluated and shown a good antimalarial activity against human malaria parasite Plasmodium falciparum in vitro. Against chloroquine sensitive (pf3d7), both Penicinoline E and Methyl marinamide displayed IC50 value of 1.56 μM and Marinamide displayed IC50 value of 25 μM respectively. In addition, against chloroquine resistant strain (pfDd2) of plasmodium falciparum they have also shown 4.68 μM, 2.34 μM and 25 μM respectively.

Seizures are an important and most common disease that affects the human body and are also caused to other neurological manifestations. Most of the people affected in the world currently are middle-aged and are suffering from many brain diseases. 50million people are affected due to epilepsy and convulsions around the world. There are many drugs that helpful and potent against epilepsy. As discussed, they have side effects, and the only solution to avoid those effects is the investigation of herbal sources for their anti-epileptic activity. One of those potent herbs is Nardostachys jatamansi. It was investigated and proved for its anti-epileptic property. The current research was planned to compare the effects of different extracts on the anti-epileptic property. In the process, double distilled water, methanol, ethanol and acetone were used as an extraction medium, and the extracts were tested for its property. Out of all the extracts, aqueous and methanol extracts showed a better activity compared with other extracts and standard drug, Diazepam.

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