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Key indicatorsSingle-crystal X-ray study T = 296 K Mean (C-C) = 0.003 Å R factor = 0.042 wR factor = 0.112 Data-to-parameter ratio = 17.8For details of how these key indicators were automatically derived from the article, see

Synthesis of a series of fourteen novel 2,3',4'-tri-subsituted-1,2-dihydro-4H,4'Hspiro[isoquinoline-3,5'-isoxazol]-4-ones was accomplished in good yield by regio and stereoselective 1,3-dipolar cycloaddition of p-R 2 -benzadoxime 4-8 with dipolarophiles (3Z)-3-The structure of the isolated products 9-23 was established through different spectroscopic techniques. X-Ray crystal structure analysis of one of the products confirms the structure and the selective region and stereochemistry of this cycloaddition. Their antitubercular activity is also evaluated.

Synthesis of a series of fourteen novel 2,2',4',5'-tetra-substituted-1,2,2',4'-tetrahydro-4H-spiro[isoquinoline-3,3'-pyrazol]-4-ones was accomplished in good yield by regio and steroselective 1,3-dipolar cycloaddition of α-chloro-aryliden-phenylhydrazones with (3Z)-3-(arylidene)-2-phenyl-2,3-dihydroisoquinolin-4(1H)-ones 4-8 with dipolarophiles [(3Z)-2-phenyl-3-(p-R 1 -phenyl)-2,3-dihydroisoquinolin-4(1H)-ones] 1-3. The structure of the isolated products 9-22 was established through different spectroscopic techniques. X-ray crystal structure analysis of one of the products confirms the structure and the selective region and stereochemistry of this cycloaddition. Their antitubercular activity is evaluated.