A series of 22 cases of tuberculous otitis media is reviewed to assess the diagnostic features of the disease. Significant clinical features are the presence of abundant pale granulations, an unexpectedly severe hearing loss, facial paralysis, the presence of normal mastoid cellular development and a past or family history of tuberculosis of any site. The otoscopic appearances of the tympanic membrane, and the symptom of painless otorrhea are not considered suspicious features. Histological examination of operative material was the diagnostic procedure in 20/22 cases, thus underlining the difficulty of diagnosis in a non‐tuberculous general population. Treatment with antituberculous chemotherapy and surgery gives good results and recent indications are that tympanoplastic surgery may be useful.

A series of 27 cases of tuberculous laryngitis is reviewed to assess the diagnostic features of the disease. The condition generally presents in males of late middle age who have pulmonary tuberculosis, although the pulmonary disease is seldom advanced. The presenting symptom is usually hoarseness, and the laryngoscopic appearances frequently mimic a tumor or chronic non-specific laryngitis: few patients correspond to the classical descriptions of the disease found in old texts. Histological examination of biopsy material is usually the diagnostic procedure, emphasizing the difficulty of diagnosis in the general population.

SummaryThe case history is presented of a patient with a massive chondrosarcoma arising from the posterior part of the nasal septum, extending into the base of the skull to involve the right middle cranial fossa. Removal of the main bulk of the tumour was accomplished by means of a cranio-facial resection, and it is hoped that useful palliation has thus been achieved.The literature relating to this rare tumour is reviewed: only seven cases have been previously described in which the tumour is believed to have arisen from the nasal septum. It is generally accepted that chondrosarcomas are radio-insensitive, and that surgical excision is the only effective form of treatment.

No abstract

The concentration of FSH and LH was determined in individual anterior pituitaries of the`intact' (bull) and gonadectomized (steer) male bovine, by differential biological assay methods. The validity of the use of NIH-FSH-ovine and NIH-LH-ovine reference preparations for these bioassays was established. The mean FSH concentration for two groups of bulls was very low: 1\ m=. \ 4\ g=m\ g and 2\ m=. \ 1\ g=m\ gNIH-FSH-S1/mg dry weight. By comparison with male rat anterior pituitary FSH concentration, bull FSH concentration was approximately one hundred times lower, so that the total amounts of FSH in a bull and in a rat anterior pituitary are approximately equivalent. The mean LH concentration for two groups of bulls was rather high: 10\m=.\5 and 13\m=.\5\ g=m\ gNIH-LH-S1/mg dry weight. Measured approximately 1 year after gonadectomy, steer anterior pituitary FSH concentration had approximately doubled while the anterior pituitary LH concentration had decreased to less than half that in the`intact' bull. This response of male bovine pituitary LH to the effect of long-term gonadectomy contrasts strikingly with the response of the male rat, in which pituitary LH increases five to tenfold after gonadectomy. These data support the concept of species differences in the mode of regulation of pituitary gonadotrophins.