No abstract

The objective of the present study was formulation and evaluation of pulsatile release tablets of Atenolol. A tablet system consisting of cores which was coated with layers of swelling and rupturable coatings. Cores containing Atenolol as model drug were prepared by direct compression with appropriate ratios of lactose and microcrystalline cellulose and then coated sequentially with different ratios of an inner swelling layer containing HPMC and an outer rupturable layer of Ethyl Cellulose. The effect of level of swelling layer and rupturable coating was investigated. The different formulation press coated by using different weight ratios of Hydroxy Propyl Methyl Cellulose (HPMC) / Ethyl Cellulose (EC) / both HPMC and EC. The optimum result was achieved in formulation containing HPMC: EC weight ratios. The F3 batch achieved a highest burst release after the lag time which is applicable pulsatile drug delivery system of Atenolol.

The goal of this study was to produce a topical gel formulation of Diclofenac diethylamine using various gelling agents, such as carbopol 934, Sodium Carboxy methyl cellulose, and alovera extract, to reduce the gastrointestinal side effects associated with oral administration. Topical medication administration can be accomplished by integrating into the gel matrix, preventing first-pass metabolism and allowing for greater local action in anti-inflammatory and analgesic purpose. The gel formulations were tested for homogeneity, grittiness, viscosity, pH, spreadability, drug content, in vitro drug release and release kinetics. The effects of polymer composition on the rate of drug release from the gel formulations were examined through dialysis membrane at 37º ± 0.5ºC. The gel formulation consisting of alovera extract (F3) was found to be suitable for topical application based on in vitro evaluation. These results suggest the feasibility of the topical gel formulation of Diclofenac diethylamine.