ÖzPurpose: The aim of this study was to evaluate increased aortic elasticity parameters and myocardial function in children with celiac disease (CD) and the effect of the subclinical myocardial damage on the elasticity parameters. Materials and Methods: Fiftytwo children with CD and 60 healthy subjects were included in the study. Patients were divided into two groups according to IgA-tissue transglutaminase (IgA-tTG) antibody results. All children's cardiac functions were assessed by conventional echocardiography and tissue Doppler (TDI) imaging. Aortic strain, distensibilty and stiffness index (SI) were calculated by M-mode echocardiography. Results:Isovolumetric contraction time and isovolumetric relaxation time values and myocardial performance index (Tei) evaluated for both ventricles by TDI were significantly higher in patients. Right ventricle Tei index value was the highest in the group of serum IgA-tTG antibody positive. Patient group exhibited significantly lower strain values and higher SI than the controls. Conclusion: Our study showed that aortic elasticity parameters in children with subclinical CD are related to arterial pressure and may be used to determine increased prematurity atherosclerosis risk. These results suggest that serious cardiovascular complications can be predicted with echocardiographic follow-up especially in children with antibody-positive CD.Amaç: Bu çalışma çölyak hatsalığı (ÇH) olan çocuklarda artmış aortik elastisite parametrelerinin ve miyokard fonksiyonlarının birlikte değerlendirildiği ve subklinik myokard hasarının esneklik parametreleri üzerine etkisinin incelenmeyi amaçlamıştır.. Gereç ve Yöntem: Çalışmaya 52 CH ve yaş ve cinsiyet yönünden benzer 60 sağlıklı çocuk alındı. Hastalar antitissue transglutaminase (anti-tTG) antibody sonuçlarına göre iki gruba ayrıldı. Tüm çocukların kardiyak fonksiyonları konvensiyonel ekokardiyografi ve doku Doppler (TDI) görüntüleme yöntemiyle değerlendirildi. M-mode ekokardiyografi ile aortik strain, distensibilite ve stiffness index (SI) hesaplandı. Bulgular: Hastaların demografik verileri ve laboratory characteristics kontrolere benzerdi. Her iki ventrikül için TDI ile değerlendirilen ICT and IRT values ve Tei index anlamlı yüksekti. RV Tei index value was the highest in the group of serum anti-tTG antibody pozitive. Patient group exihibited significantly lower strain values and higher SI than the controls. Sonuç: Bu çalışma subklinik CD'li çocuklarda aortik elastisite parametreleri ile prematür ateroskleroz riskinin arttığı ve bunun arteriyel basınç ile ilişkili olduğunu gösterdi. Bu sonuçlar özellikle antikor pozitif CD'li çocuklarda ekokardiyografik izlem ile oluşabilecek ciddi kardiyovasküler komplikasyonların öngörülebileceğini düşündürmektedir.

The aim of this study was to investigate the prognostic value of complete blood count parameters, presence of pulmonary hypertension (PH) and valve failure in newborns with hypoxic ischemic encephalopathy (HIE). Materials and Methods: 115 term newborns with Sarnat Stage 2 and 3 with HIE and 90 healthy newborns were included in this retrospective study. Echocardiographic examination, red blood cell distribution width (RDW), platelet distribution width (PDW), and C-reactive protein (CRP) values at the first six hours and at 72 hours after the cooling treatment were compared with controls. Results: There was a relationship between presence of mitral regurgitation (MR), aortic regurgitation (AR), and persistent PH and death. The mean RDW, PDW and CRP levels at the first six and after 72 hours were significantly higher in infants with HIE when compared with the control group, and these parameters were significantly increased in the stage 3 group. A significant relationship was found between the increase in RDW and CRP values and the presence of MR, AR and mortality. Conclusion: The degree of PH and presence of valvular insufficiency are important parameters in determining prognosis in HIE. Also, simple blood tests such as RDW and CRP and the echocardiographic evaluation are found to be correlated with hospitalization period and mortality and may be a guide in prognosis. Amaç: Bu çalışmanın amacı hipoksik iskemik ensefalopati(HİE) tanılı yenidoğanlarda tam kan sayımı parametrelerinin, pulmoner hipertansiyon (PH) ve kapak yetmezliği varlığının prognostik değerini incelemektir. Gereç ve Yöntem: Sarnat ölçeğine göre evre 2 ve 3 HİE olan 115 term yenidoğan ile 90 sağlıklı yenidoğan hastanın verileri retrospektif olarak değerlendirilmiştir. İlk 6 saatteki ve hipotermi tedavisi sonrası 72.saatteki ekokardiyografik inceleme, kırmızı kan hücresi dağılım genişliği (RDW), trombosit dağılımı genişliği (PDW) ve CRP değerleri, kontrol grubu ile karşılaştırılmıştır. Bulgular: Mitral yetmezlik, aortik yetmezlik ile persistan PH ve ölüm arasında anlamlı bir ilişki bulunmuştur. İlk 6 saat ve 72. saatteki ortalama RDW, PDW ve CRP değerleri kontrol sağlıklı gruba göre hastalarda daha yüksek çıkmıştır. Özellikle evre 3 HİE hastalarında daha belirgin olmak üzere, bu parametrelerin 72.saatte ilk 6 saate göre önemli oranda arttığı görülmüştür. RDW, CRP değerlerinde artış ile MY, AY olması ve mortalite arasında anlamlı bir ilişki bulunmuştur. Sonuç: Çalışmamız PH derecesi ve kapak yetmezliği varlığının, HİE'de prognozu belirlemede önemli parametreler olduğunu göstermektedir. RDW ve CRP gibi basit kan testleri ile ekokardiyografik değerlendirme yapılması yatış zamanı ve mortalite ile ilişkili olup prognozu belirlemede rehber olabilir.

The aim of this study is to investigate frequency of patent ductus arteriosus (PDA) according to gestational week, spontaneous closure rate and effectiveness of oral treatment in closure in premature infants. Materials and Methods: Patients who had only PDA in neonatal intensive care unit in 2013-2016 were retrospectively screened and 231 patients included in the study. The demographic data of the patients were recorded and they were divided into groups according to gestational week; size and gradient of PDA. Left atrium/aorta ratio and left ventricular functions were evaluated echocardiographically in 4.6±1.5th day of birth. Results: The frequency of PDA in our neonatal intensive care unit was 10.8% (231/2127 patients). Significant PDA was present in 41(17.7%) of patients, mean diameter of ductus was 2.5±0.5 and the left atrium/aorta ratio was 1.37±0.15 in these patients. Ibuprofen (po) was given to 8(19.5%) of the patients having hemodynamically significant PDA. All of the patients given medical closure treatment were <32 weeks of gestation and <1500g. Surgical closure was required in only one patient. Conclusion: It is still controversial that PDA closure treatment should be given when and to which preterm infants. As only one of the patients needed surgery with the conservative approach, we suggest that treatment decision should not be given early in premature infants with PDA and they should be closely monitored.