Flexible electronics have suggested tremendous potential to shape human lives for more convenience and pleasure. Strenuous efforts have been devoted to developing flexible organic field-effect transistor (FOFET) technologies for rollable displays, bendable smart cards, flexible sensors and artificial skins. However, these applications are still in a nascent stage for lack of standard high-performance material stacks as well as mature manufacturing technologies. In this review, the material choice and device design for FOFET devices and circuits, as well as the demonstrated applications are summarized in detail. Moreover, the technical challenges and potential applications of FOFETs in the future are discussed.

Purpose: Anti-CD19 chimeric antigen receptor (CAR) T cells represent a novel immunotherapy and are highly effective in treating relapsed/refractory B-cell non-Hodgkin's lymphoma (B-NHL). How tumor microenvironment influences clinical response to CAR T therapy remains of great interest.Patients and Methods: A phase I, first-in-human, doseescalation study of anti-CD19 JWCAR029 was conducted in refractory B-NHL (NCT03355859) and 10 patients received CAR T cells at an escalating dose of 2.5 Â 10 7 (n ¼ 3), 5 Â 10 7 (n ¼ 4), and 1 Â 10 8 (n ¼ 3) cells. Core needle biopsy was performed on tumor samples collected from diffuse large B-cell lymphoma patients on Day À6 (1 day before lymphodepletion) and on Day 11 after CAR T-cell infusion when adequate CAR T-cell expansion was detected.Results: The overall response rate was 100%, with 6 of 9 (66.7%) evaluable patients achieving complete remission. The most common adverse events of grade 3 or higher were neutropenia (10/10, 100%), anemia (3/10, 30%), thrombocytopenia (3/10, 30%), and hypofibrinogenemia (2/10, 20%). Grade 1 cytokine release syndrome occurred in all patients and grade 3 neurotoxicity in 1 patient. The average peak levels of peripheral blood CAR T cells and cytokines were similar in 3 different dose levels, but CAR T cells were significantly higher in patients achieved complete remission on Day 29. Meanwhile, RNA sequencing identified gene expression signatures differentially enriched in complete and partial remission patients. Increased tumor-associated macrophage infiltration was negatively associated with remission status.Conclusions: JWCAR029 was effective and safe in treating refractory B-NHL. The composition of the tumor microenvironment has a potential impact in CAR T therapy response.

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A highly customizable hybrid sensor system, composed of a silicon integrated circuit (IC) chip and an organic field effect transistor (OFET) transducer, is proposed for Internet of Everything (IoE). In such a system, the silicon IC chip performs high performance and complex signal processing, and the OFET transducer provides flexible or conformable large area coverage and more friendly interfaces to integrate different sensing materials. A low trap-state density OFET (LTDOFET) technology is developed for such a hybrid system, owning features of low-cost solution printing processes, low operation voltage and excellent operational stability. This technology has been implemented with various materials and processes, indicating its generality. Several sensor applications built based on this device technology are also reviewed, proving the LTDOFET technology would be promising for highly customizable sensor systems towards the IoE era.

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