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A New Route for the Synthesis of Ozagrel Hydrochloride. -Starting from p-tolualdehyde, a new cost efficient synthetic route to title compound (VI), a highly selective thromboxane A2 inhibitor, is described. The overall yield is 72% compared to 34% realized in a previously reported method. -(YU, C.; ZHAO, B.; ZHAO, Y.; LIN*, J.; Org.

Key indicators: single-crystal X-ray study; T = 293 K; mean (C-C) = 0.003 Å; disorder in main residue; R factor = 0.042; wR factor = 0.117; data-to-parameter ratio = 13.5.The asymmetric unit of the title compound, C 26 H 16 F 6 O 2 , contains one half of the molecule situated on an inversion centre. In the rod-like molecule, the two terminal benzene rings form a dihedral angle of 71.9 (1) with the central benzene ring. The trifluoromethyl group is rotationally disordered over two orientations in a 0.53 (1):0.47 (1) ratio. The crystal packing exhibits no classical intermolecular interactions. Related literature