Recently, there have been many attempts to extend the notion of proper time to quantum mechanics with the use of quantum clocks. Using a similar idea combined with the relativistic mass-energy equivalence, we consider an accelerating massive quantum particle with an internal clock system. We show that the ensuing evolution from the perspective of the particle's internal clock is non-Hermitian. This result does not rely on specific implementations of the clock. As a particular consequence, we prove that the effective Hamiltonian of two gravitationally interacting particles is non-Hermitian from the perspective of the clock of either particle.