Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with poorly understood clinical heterogeneity, underscored by significant differences in patient age at onset, symptom progression, therapeutic response, disease duration, and comorbidity presentation. We perform a patient stratification analysis to better understand the variability in ALS pathology, utilizing postmortem frontal and motor cortex transcriptomes derived from 208 patients. Building on the emerging role of transposable element (TE) expression in ALS, we consider locus-specific TEs as distinct molecular features during stratification. Here, we identify three unique molecular subtypes in this ALS cohort, with significant differences in patient survival. These results suggest independent disease mechanisms drive some of the clinical heterogeneity in ALS.

Alternating current (AC) electrolysis is receiving increased interest as a versatile tool for mild and selective electrochemical transformations. This work demonstrates that AC can enable the concept of a stirring-free electrochemical reactor where the periodic switch of electrode polarity, inherent to AC, provides uniform electrolysis across the whole volume of the reactor. Such design implies a straightforward approach for scaling up electrosynthesis. This was demonstrated on the range of electrochemical transformations performed in three different RVC-packed reactors on up to a 50-mmol scale. Redox-neutral, oxidative, and reductive processes were successfully implemented using the suggested design and the applicable frequency ranges were further investigated for different types of reactions. The advantages of the AC-enabled design -such as the absence of stirring and a maximized surface area of the electrodes -provide the possibility for its universal application both for small-scale screening experimentation and large-scale preparative electrosynthesis without significant optimization needed in between.

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In 1988, the U. S. Congress provided $1.4 million to six Aleut communities in Alaska as restitution for damage done to their churches by U. S. forces stationed in the Aleutians during World War II. The residents of these communities had been forcibly evacuated and interned for up to three years in camps in southeast Alaska where many died. At the request of the Aleuts, restitution to the Orthodox churches was given a special place in the U. S. decision to make reparations. The Aleutian/Pribilof Islands Association, a non-profit organization, has been charged by Congress with assessing the damage and estimating the cost of restoration. The assessment project, begun in November 1991, has utilized the expertise of an architect and art conservator to examine structures and church furnishings of these churches and has reached some preliminary conclusions: 1) The stress of travel for those icons and liturgical vessels which accompanied the evacuees was significant and damage related to that travel is evident today; 2) The churches themselves were often targets of vandalism and looting by the American troops; 3) the churches were left without regular maintenance in the harsh climate of the Aleutians for three years; 4) the Aleuts were destitute on their return and could not restore the buildings to their former condition; 5) the results of makeshift repairs in the immediate post-war era are evident today in a general state of deterioriation. The final report to Congress on this project is due in the Spring 1993.