A B S T R A C TPoly(glycerol adipate) (PGA) is a biodegradable, biocompatible, polymer with a great deal of potential in the field of drug delivery. Active drug molecules can be conjugated to the polymer backbone or encapsulated in selfassembled nanoparticles for targeted and systemic delivery. Here, a range of techniques have been used to characterise the enzymatic degradation of PGA extensively for the first time and to provide an indication of the way the polymer will behave and release drug payloads in vivo. Dynamic Light Scattering was used to monitor change in nanoparticle size, indicative of degradation. The release of a fluorescent dye, coupled to PGA, upon incubation with enzymes was measured over a 96 h period as a model of drug release from polymer drug conjugates. The changes to the chemical structure and molecular weight of PGA following enzyme exposure were characterised using FTIR, NMR and GPC. These techniques provided evidence of the biodegradability of PGA, its susceptibility to degradation by a range of enzymes commonly found in the human body and the polymer's potential as a drug delivery platform.

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In 2007, near Harrogate, in North Yorkshire, a Viking-period hoard was discovered with a Carolingian silver-gilt cup. This article examines this cup, highlighting Oriental, Central Asian and classical parallels in both metal and pottery for the cup’s form and decoration. The overall significance of the cup’s iconography has already been thoroughly discussed by Professor Egon Wamers, who proposed that the scenes on the cup are paralleled in the early ninth-century Stuttgart Psalter. This article proposes that Oriental forms and decorative elements in metalwork were channelled to the West through diplomatic contacts and trade by way of a complex of routes by land and sea, as well as possibly by refugees from Islamic conquests.