White adipose tissue plays an important role in physiological homeostasis and metabolic disease. Different fat depots have distinct metabolic and inflammatory profiles and are differentially associated with disease risk. It is unclear whether these differences are intrinsic to the pre-differentiated stage. Using single-cell RNA sequencing, a unique network methodology and a data integration technique, we predict metabolic phenotypes in differentiating cells. Single-cell RNA-seq profiles of human preadipocytes during adipogenesis in vitro identifies at least two distinct classes of subcutaneous white adipocytes. These differences in gene expression are separate from the process of browning and beiging. Using a systems biology approach, we identify a new network of zinc-finger proteins that are expressed in one class of preadipocytes and is potentially involved in regulating adipogenesis. Our findings gain a deeper understanding of both the heterogeneity of white adipocytes and their link to normal metabolism and disease.

We investigate patterns of adoption of 175 social media services and Web businesses using data from Google Trends. For each service, we collect aggregated search frequencies from 45 countries as well as global averages. This results in more than 8.000 time series which we analyze using economic diffusion models. The models are found to provide accurate and statistically significant fits to the data and show that collective attention to social media grows and subsides in a highly regular manner. Regularities persist across regions, cultures, and topics and thus hint at general mechanisms that govern the adoption of Web-based services

The increasing role of recommender systems in many aspects of society makes it essential to consider how such systems may impact social good. Various modifications to recommendation algorithms have been proposed to improve their performance for specific socially relevant measures. However, previous proposals are often not easily adapted to different measures, and they generally require the ability to modify either existing system inputs, the system's algorithm, or the system's outputs. As an alternative, in this paper we introduce the idea of improving the social desirability of recommender system outputs by adding more data to the input, an approach we view as providing 'antidote' data to the system. We formalize the antidote data problem, and develop optimization-based solutions. We take as our model system the matrix factorization approach to recommendation, and we propose a set of measures to capture the polarization or fairness of recommendations. We then show how to generate antidote data for each measure, pointing out a number of computational efficiencies, and discuss the impact on overall system accuracy. Our experiments show that a modest budget for antidote data can lead to significant improvements in the polarization or fairness of recommendations.

In this paper we address the problem of finding explanations for collaborative filtering algorithms that use matrix factorization methods. We look for explanations that increase the transparency of the system. To do so, we propose two measures. First, we show a model that describes the contribution of each previous rating given by a user to the generated recommendation. Second, we measure the influence of changing each previous rating of a user on the outcome of the recommender system. We show that under the assumption that there are many more users in the system than there are items, we can efficiently generate each type of explanation by using linear approximations of the recommender system's behavior for each user, and computing partial derivatives of predicted ratings with respect to each user's provided ratings.

Fairness concerns about algorithmic decision-making systems have been mainly focused on the outputs (e.g., the accuracy of a classifier across individuals or groups). However, one may additionally be concerned with fairness in the inputs. In this paper, we propose and formulate two properties regarding the inputs of (features used by) a classifier. In particular, we claim that fair privacy (whether individuals are all asked to reveal the same information) and need-to-know (whether users are only asked for the minimal information required for the task at hand) are desirable properties of a decision system. We explore the interaction between these properties and fairness in the outputs (fair prediction accuracy). We show that for an optimal classifier these three properties are in general incompatible, and we explain what common properties of data make them incompatible. Finally we provide an algorithm to verify if the trade-off between the three properties exists in a given dataset, and use the algorithm to show that this trade-off is common in real data.