The current investigation was carried out to study the protective effect of vitamin E (VE) on the associated disturbances of hematological, renal, and hepatic functions in male rats produced in potassium bromate (KBrO 3 ) treated rats. Twenty-four rats were divided randomly into four groups: First group: served as control group. Second group: rats were received 50 mg/kg b.wt. of KBrO 3 orally. Third group: rats were received 30 mg/kg b.wt. of VE orally. Fourth group: rats were received 30 mg/kg b.wt. of VE orally an hour before administration of KBrO 3 (50 mg/kg b.wt.) orally. The experiment continued for five successive weeks. Results showed that the treatment with KBrO 3 revealed a significantly decrease in the mean of the body weight, red blood corpuscles (RBCs), white blood cells (WBCs), blood platelets (PLTs), hemoglobin (HB), hematocrit value (HCT) comparing to the control group. Whereas, the serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) enzymes, urea, uric acid, creatinine, were obviously elevated in KBrO 3 treated group comparing with control group. The treatment with VE+KBrO 3 ameliorated all the hematological, renal, and hepatic parameters tested. It is clear from the present results that VE reduced the severity of KBrO 3 . This could be mediated by its potent antioxidant effects.

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