This work is a contribution to a better use of Grangea maderaspatana belonging to family Asteracea as a medicinal plant for its phytochemicals.  Extracts of different parts of Grangea maderaspatana were thus screened for their phytochemicals, including phenolics, tannins and flavonoids contents and total antioxidant contents. The extracts were obtained from the roots, flowers, leafy branches and the whole plant using hexane, dichloromethane, ethyl acetate and methanol. The phytochemical screening was carried out by means of thin layer chromatography, colorimetric and precipitation reactions. Total phenolics contents, total flavonids et totat antioxidants contents were evaluated by spectrophotometric methods. The phytochemical screening revealed that G. maderaspatana different parts contained phenolics, tannins, flavonoids, alkaloids, sterols and terpenes at different content. Total phenolics contents ranged from 0.051 to 93.455 mg GAE/g of extract in dichloromethane extract of leafy branches and in the ethyl acetate extract of flowers, respectively. Those of total flavonoids ranged from 82.984 in the roots methanolic extract to 753.337 mg QE/g in the ethyl acetate extract of flowers. Total antioxidant contents, assessed by ,  and  methods are highest in ethyl acetate extracts compared to others extraction solvents. maderaspatana contains a variety of secondary metabolites whose levels vary according to the plant part used.