Background: Fournier’s gangrene is a rare and rapidly progressive, necrotizing fasciitis affecting the external genitalia and perineum. Based on the case series that have been reported, the incidence rate of this case is 88% with mortality rate of 20%-40%. The study aims to share our policy in managing Fournier’s gangrene and identifying risk factors that can affect the outcome of defect closure.Method: The medical records of 10 patients with Fournier’s gangrene who presented at the Dr. Soetomo Hospital Surabaya from January 2017 to December 2018 were reviewed retrospectively. We analyzed characteristics of the patients, risk factors, methods of defect closure, and case outcome. There are 10 Fournier’s gangrene patients at Dr. Soetomo Academic General Hospital from January 2017 to December 2018. We analyzed the patient’s medical records retrospectively on the patient’s characteristics, risk factors, method of closing Fournier’s gangrene defects, and the final outcome of the case.Results: There were ten men enrolled in the study, and the mean age was 49.3 ± 11.51 years. All patients received broad-spectrum antibiotic therapy, and extensive surgical excision. This study found that diabetes mellitus and uncontrolled patient blood sugar levels, statistically there is no effect on failure of defect closure in Fournier gangrene patients, but clinically, the relative risk value shows that blood glucose levels have a risk factor of 6 times. increasing the incidence of failure to close the Fournier gangrene defect.Conclusions: Fournier’s gangrene is still considered a severe disease with fairly high mortality rate. Early recognition of predisposition factors associated with invasive and aggressive treatment options is very important in efforts to to reduce morbidity.

Background : Burn injury is a trauma with high morbidity and mortality that requires special management from the start. stem cells have generated great hopes for the treatment of numerous conditions including burns. The Metaanalysis was performed for these preclinical studies to assess the efficacy and possible mechanisms of Amniotic Membrane Mesenchymal Stem Cell (AM-MSC) in treating burn wounds.Methods: . Seven studies identified by searching PubMed, MEDLINE,  databases from inception to October 2020. In addition, a manual search of references of studies was performed to obtain potential studies. Stata 16 was used for all data analysis.Results : The overall meta-analysis showed that AM-MSC therapy significantly improved burn healing rate (SMD 3.34, 95% CI 1.82 to 4.86), irrespective of transplant type, burn area, and treatment method in the control groupConclusions: Metaanalysis showed that AM-MSC therapy exerts appears to exert a positive effect in burn wound healing, mainly through angiogenesis and anti-inflammatory actions.  There is, therefore, justification for continued efforts to evaluate variations in future clinical studies using stem cells to treat a burn wound in order to maximize the effectiveness.  the use of stem cells as an adjunct to first-line therapies in burns.