Introduction: We assessed the clinical-epidemiological profile of acquired immune deficiency syndrome (AIDS) patients in the Santos region (São Paulo state) with the highest AIDS prevalence in Brazil. Methods: Information was extracted from records of 409 AIDS-infected patients hospitalized between 2011 and 2016. Results: Human immunodeficiency virus (HIV) was diagnosed in 24.7% of patients during admission, and 39.6% of already diagnosed patients received highly active antiretroviral therapy (HAART) irregularly. The mortality rate was 19.1%, and the main secondary manifestations were neurotoxoplasmosis and tuberculosis. Conclusions: AIDS patients in the Santos region had high rates of late diagnosis and low treatment adherence.
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