As residências multiprofissionais e em área profissional da saúde foram criadas em 2005, a partir da promulgação da Lei n° 11.129. Em termos técnicos, trata-se de um programa de cooperação intersetorial para favorecer a inserção qualificada dos jovens profissionais da saúde no mercado de trabalho, particularmente em áreas prioritárias do Sistema Único de Saúde.
Os princípios e diretrizes do SUS, inclusive, orientam as Residências, a partir de necessidades e realidades locais e regionais. Podemos dizer que a Residência Multiprofissional em Saúde é uma Pós-Graduação Lato Sensu como todo curso de especialização, só que voltada para a educação em serviço e destinada às categorias que integram a área de saúde.
Com duração mínima de dois anos, os programas têm ênfase na prática (por isso utiliza-se o termo educação em serviço). A carga horária prática é um diferencial e capacita o profissional de saúde para o exercício da sua função.
Nessa semana, iremos abordar vários temas sobre residências, editais, como se informar e pesquisar e como traçar um planejamento de estudo, recebendo vários palestrantes durante o dia 07 a 11 de Novembro de 2022.
Background:
Leishmaniasis, a still important public health problem, exhibits environmental risk factors such as
massive migrations, urbanization, and deforestation. WHO research for Leishmaniasis has been mainly focused on the development
of new tools, such as diagnostic tests, drugs, and vaccines. During the drug development strategy, only a few
compounds seem promising and call for further study after the in vitro and in vivo preclinical tests.
Objective:
In this review, our group aimed to highlight the utmost research done during 2014 to 2019 in the fields of natural
and synthetic compounds, as well as repurposed drugs and new formulations tested in vivo for Leishmania spp.
Method:
Based on the literature search, we used the databases MEDLINE, PUBMED, CAPES PERIODIC and ELSEVIER
to delineate an interval of the last 5 years of research on each field.
Results:
Among the natural compounds tested, allicin and a fraction of potato tuber extract showed the most promising antileishmanial
activity. Concerning synthetic compounds, quinolines, bornyl ester, thymol, benzoxaborole and nitroimidazole
derivatives exhibited encouraging results. Moreover, repositioned alternatives involved combinations with known drugs and
monotherapy protocols as well. In these years, new formulations were widely assessed as drug delivery systems, such as nanoparticles,
micelles and liposomes in polymer conjugations.
Conclusion:
Drug repurposing and new formulations of already-known drugs are worthwhile approaches to promptly introduce
new treatment schemes to Leishmaniasis. Nevertheless, the interest in new synthetic compounds and new formulations
brings light to new treatment proposals and are notable lines of research.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.