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A centrifugal blood pump is a common type of the pump used as a left ventricular assist device (LVAD) in the medical industries. The reduction of the LVADs hemolysis level to reduce the blood damage is one of the major concerns in designing of such devices. Also, the enhancement of the LVADs efficiency to decrease the battery size is another design requirement. The blood damage critically depends on the state of the blood being pumped. Besides the blood state, the blood damage also depends on the pump impeller and volute geometries. In this research, a multi-objective optimization of a centrifugal blood pump is performed. A complete 3D-optimization platform is established for both impeller and volute of a centrifugal blood pump consisting of parametric modeling, automatic mesh generation, computational fluid dynamics (CFD) simulation, and optimization strategy. A

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