Rezvani• We applied magnetics NiFe 2 O 4 as a recoverable catalyst in the multicomponent reaction of substituted pyrroles • Magnetic NiFe 2 O 4 could be recovered from the reaction easily with an external magnet and be used nine times without significant activity loss.
•The catalytic activity of magnetic NiFe 2 O 4 nanoparticles were less studied in organic reactions. • The reaction conditions is mild and the process of catalyst preparation is simple.• The yields are high.In this study nickel ferrite magnetic nanoparticles were applied as an efficient and reusable catalyst in the four-component synthesis of substituted pyrroles under neat conditions. The reaction was conducted using various amounts of catalyst at different temperatures and finally, application of 5 mol% of catalyst at 100°C was determined as the optimum reaction conditions. Results showed that nickel ferrite nanoparticles could catalyze the reaction at relatively short times (3-4 h) with high to excellent yields (70-96%). The catalyst could be recovered easily using an external magnetic field and be reused for nine times without any significant activity lost.
Reaction of aromatic α-bromoketones, sodium azide and aromatic or aliphatic terminal acetylenes in the presence of Cu/Cu(OTf) 2 following the classical method (aqueous acetonitrile at room temperature) and under microwave irradiation (H 2 O at 85 • C) leads to 1,4-disubstituted 1,2,3-triazoles as the final products after simple filtration.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.