Background Various observations have suggested that the course of COVID-19 might be less favourable in patients with inflammatory rheumatic and musculoskeletal diseases receiving rituximab compared with those not receiving rituximab. We aimed to investigate whether treatment with rituximab is associated with severe COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases.Methods In this cohort study, we analysed data from the French RMD COVID-19 cohort, which included patients aged 18 years or older with inflammatory rheumatic and musculoskeletal diseases and highly suspected or confirmed COVID-19. The primary endpoint was the severity of COVID-19 in patients treated with rituximab (rituximab group) compared with patients who did not receive rituximab (no rituximab group). Severe disease was defined as that requiring admission to an intensive care unit or leading to death. Secondary objectives were to analyse deaths and duration of hospital stay. The inverse probability of treatment weighting propensity score method was used to adjust for potential confounding factors (age, sex, arterial hypertension, diabetes, smoking status, body-mass index, interstitial lung disease, cardiovascular diseases, cancer, corticosteroid use, chronic renal failure, and the underlying disease [rheumatoid arthritis vs others]). Odds ratios and hazard ratios and their 95% CIs were calculated as effect size, by dividing the two population mean differences by their SD. This study is registered with ClinicalTrials.gov, NCT04353609.

Objectives To evaluate the reliability of the OMERACT paediatric ultrasound (US) synovitis definitions and scoring system in JIA. Methods Thirteen sonographers analysed 75 images for the presence/absence of elementary lesions (binary scoring) and for grading synovitis, synovial hypertrophy, effusion and Doppler signals. Static US images of the second metacarpophalangeal joint (MCP-II), wrist, elbow, knee and ankle in JIA patients at different ages and different disease stages were collected with standardized scanning by two experienced sonographers. Intra- and inter-reader reliability were analysed with kappa coefficients. Results Intra-reader reliability was good for binary scoring (Cohen’s kappa 0.62, range 0.47–0.75), synovitis and synovial hypertrophy; excellent for Doppler signals (quadratic weighted kappa 0.77, 0.66–0.86; 0.76, 0.61–0.84; and 0.87, 0.77–0.94, respectively); and moderate for effusion (0.55, 0.24–0.76). Inter-reader reliability was good for synovitis and synovial hypertrophy (Light’s kappa 0.68, 95% CI: 0.61, 0.75 and 0.63, 0.54–0.71, respectively), excellent for Doppler signals (0.85, 95% CI: 0.77, 0.90), and moderate for binary scoring and effusion (0.48, 95% CI: 0.36, 0.64 and 0.49, 0.40–0.60, respectively). We obtained the best scores for the knee (0.71, 0.54–0.85) except for Doppler signals, with reliability higher for MCP-II. We found a trend toward better results in older children. Conclusions This is the first study establishing the reliability of the OMERACT paediatric US synovitis definitions and scoring system in the five most commonly affected joints in JIA. The reliability was good among a large group of sonographers. These results support the applicability of these definitions and scoring system in clinical practice and multicentre studies.

Le concept de privacy emprunté à l'anglais désigne usuellement le lien entre la personne et les technologies de l'information. Son apparition remonterait au dévelop-pement de la photographie dans la presse écrite au XIX e siècle (Warren et Brandeis, 1890). En France, le terme correspond assez largement au concept de « donnée à caractère personnel » au centre de la loi Informatique et Libertés de 1978. La qualification d'une donnée à caractère personnel, son traitement et sa connexion à d'autres bases de données deviennent trois enjeux centraux de l'informatisation. Aujourd'hui, alors que la communication électronique a connu de nombreuses évolu-tions, c'est le même dispositif juridique, révisé pour tenir compte de la directive européenne de 1995, qui traite de la question de la privacy. Avec la diffusion massive d'Internet et des usages qui lui sont associés, on peut néanmoins légitimement se demander si la notion est encore adaptée. La finalité de cet article est de montrer que les transformations en cours dans la communication réinterrogent fortement le concept de privacy 1 et invitent à repenser de manière radicalement différente notre manière de définir et de protéger la vie privée.

Du point de vue des usagers, c'est l'essence même de la vie privée comme valeur à préserver qu'en dernier lieu les frontières mouvantes et subjectives des zones vécues comme publiques, privées, semi-publiques etc. (Cardon, 2008) semblent venir interroger. L'individu contemporain, en quête d'autonomie (de Singly, 2003), en exploration de soi et de ses liens sociaux Cet article des Editions Lavoisier est disponible en acces libre et gratuit sur lcn.revuesonline.com

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