Life in the city for any youth can be challenging without a proper support network. For Indigenous youth in particular, the unique burden of intergenerational trauma due to the residual effects of colonialism (e.g. residential schools and historical outlawing of traditional practices) can contribute to both unhealthy behaviors and a continuation of “culturally unsafe” spaces. As a response to these challenges, this article examines the positive effects that a grassroots film creation and production program in a major urban centre in Saskatchewan, Canada, had on participating Indigenous youth. Community-based researchers from the Indigenous Peoples’ Health Research Centre observed how a culturally safe space created the conditions to enable youth to become creative through the arts in an environment supported by an intergenerational network of Nêhiyaw (Plains Cree) kinship relationships called wâhkôtowin. The article also argues that the effectiveness of culturally safe spaces can benefit from recognizing the operation of ethnogenetic processes in contemporary environments.