A family of gold(I)-phosphonium-phosphines complexes was synthesized thanks to an efficient 5-step strategy, which involve a phospha-Fries rearrangement. It enables the facile variation of the phosphonium moiety. All the complexes...

A phosphine gold(I) and phosphine‐phosphonium gold(I) complexes bearing a fluorescent coumarin moiety were synthesized and characterized. Both complexes displayed interesting photophysical properties: good molar absorption coefficient, good quantum yield of fluorescence, and ability to be tracked in vitro thanks to two‐photon imaging. Their in vitro and in vivo biological properties were evaluated onto cancer cell lines both human and murine and into CT26 tumor‐bearing BALB/c mice. They displayed moderate to strong antiproliferative properties and the phosphine‐phosphonium gold(I) complex induced significant in vivo anti‐cancer effect.

Herein we report the synthesis of a new P-chirogenic triazole-based phosphine according to the ephedrine methodology. Upon reaction with late transition-metal derivatives, Rh(I) and Pd(II), phosphine-triazole forms complexes with bidentate P,N coordination, as demonstrated by spectroscopic and X-ray crystallographic analyses. First experiments in asymmetric catalysis showed the catalytic potential of this new chiral P,N-type ligand.