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Protein-calorie undernutrition in the period of rapid brain growth during gestation and suckling in DBA/2J mice resulted in persistent reduction in body and brain weights, despite normal diet from weaning. No significant changes in brain or spinal cord were observed with light microscopy. Behavioral tests revealed that experimental animals had more frequent feeding with smaller meal size, increased activity in the presence of environmental stimulation, fewer errors in learning spatial discrimination reversals, and more errors in problemsolving maze tests. Activity in dark environment, bar pressing for food on a progressive ratio schedule, and foot shock avoidance conditioning showed no significant difference between control and experimental groups. This behavioral profile supports an hypothesis of higher set-point for arousal resulting from early life nutritional deprivation which influences reversal learning and problem solving. (24:167-172, 1973)

Cardiobacterium hominis, a recently recognized Gram-negative pathogen, was recovered in blood cultures from a 65-year-old man with indolent endocarditis of previously normal heart valves. Despite the low virulence of the organism, major cardiac damage required valvular replacement, and there were multiple cerebral emboli with development of a mycotic aneurysm. After bacteriological cure, he died of a ruptured aneurysm.