Background: Malaria and HIV are endemic in Cameroon. But data on the prevalence of coinfection with malaria and HIV in Cameroonian children are essentially absent. This study was aimed at determining the prevalence of coinfection with malaria and HIV among children in Yaoundé, so as to advice control policies. Methods: In a cross-sectional survey, children (≤15 years) were recruited from 3 communities in Yaoundé namely: Efoulan, Biyem-assi and Cité-verte. A semi-structured questionnaire was used to collect demographic data. Participants were screened for malaria parasites by the examination of Giemsa-stained blood films meanwhile participants were screened for HIV following Cameroon's national algorithm. The Pearson's chi-square test was performed as part of the statistical analyses. Statistical significance was set at p < 0.05. Result: Three hundred and ten (310) children took part in the study. The mean age (±SD) of the participants was 75.64 (±63.23) months and a majority of them were males (56