Abstract. Buccal patches for the delivery of atenolol using sodium alginate with various hydrophilic polymers like carbopol 934 P, sodium carboxymethyl cellulose, and hydroxypropyl methylcellulose in various proportions and combinations were fabricated by solvent casting technique. Various physicomechanical parameters like weight variation, thickness, folding endurance, drug content, moisture content, moisture absorption, and various ex vivo mucoadhesion parameters like mucoadhesive strength, force of adhesion, and bond strength were evaluated. An in vitro drug release study was designed, and it was carried out using commercial semipermeable membrane. All these fabricated patches were sustained for 24 h and obeyed first-order release kinetics. Ex vivo drug permeation study was also performed using porcine buccal mucosa, and various drug permeation parameters like flux and lag time were determined.

Ondansetron HCl is effective in the treatment of nausea and vomiting caused in such condition it is difficult to administer drug with a glass of water; hence it is beneficial to administer such drugs as orodispersible. Thus in the present study an attempt has been made to mask the taste of Ondansetron HCl and to formulate orodispersible with good mouth feel so as to prepare a "patients friendly dosage form.". The tablets prepared by sublimation method. The prepared tablets were evaluated for various pharmaceutical characteristics such as hardness, % friability, weight variation, drug content all the results were within the IP. Limit. The tablets prepared possess a weight variation in the range 99 to 101 mg which is below ± 7.5%, hardness of 2.7 to 3.0 kg/cm², percentage friability of 0.42 to 0.73%. The wetting time of Ondansetron HCl fast dissolving tablets was found to be in the range of 44 to 81 sec. The prepared formulations shows water absorption ratio in the range of 72 to 85%. The percentage drugs content of the tablets were found to be between 98.24 to 101.20% of Ondansetron HCl. In-vitro disintegration time the formulations OHS4 and OHS8 were found to be promising and showed a 28 sec and 32 sec respectively. Based on the in-vitro disintegration time and dissolution studies formulations OHS4 and OHS8 were found to be promising and showed a disintegration time of 28 sec and 32 sec respectively. Formulation OHS4 containing camphor showed highest drug release 99% within 8 min. Formulation OHS8 showed highest drug release 90% within 8 min. From FTIR and DSC study results reveals that there is no interaction between drug and any other formulation excipients. In case of stability study there is decrease in disintegration time, wetting time was observed. The results concluded that fast dissolving tablets of Ondansetron HCl showing enhanced dissolution will lead to improved bioavailability and effective therapy. This drug resin complex was compressed in tablets by adding diluents to see its mouth feel properties and bitter taste is masked.