Deha-Prakriti (DP) is Ayurveda’s one-of-a-kind contribution, established at conception and cannot be changed throughout one’s life. There are seven varieties of DP. Vataja, Pittaja, Kaphaja (Shleshmala), Samsargaja [combination of two Dosha] i.e. Vata-Pittaja, Pitta-Kaphaja, Kapha-Vataja, Sannipataja [combination of three Dosha] i.e. Vata-Pitta-Kapha. The first and most important aspect of Dashavidha-parikshyabhavas (ten important examination factors to be known by the physician) is the DP assessment since it plays a crucial part in Rogi-Pariksha (evaluation of the patient) and Roga-Pariksha (assessment of the disease). DP allows a physician to assess the condition of Koshtha (digestion system), Agni (digestive capacity), Bala (strength), and Ayu (life-span) in both healthy and diseased people. It may also help a physician forecast illness susceptibility, severity of signs and symptoms, disease activity scores, and bio-markers such as hematological, pathological, and biochemical indicators. Based on the severity, a physician may prepare the appropriate diet-chart, medication, dose, Anupana (co-drink to the primary medicine), and treatment technique (either Shodhana karma- purificatory measure or Shamana karma- Palliative measure). In light of the above facts, the current study aims to explore the DP-based susceptibility to Amavata, its severity, and the research strategy for future studies. An overview of evidence-based study on developing Deha-Prakriti with diverse illness conditions may be provided in this work, allowing for the revalidation of ayurvedic literature-based assertions.

Background: Amavata (Rheumatoid Arthritis) is a chronic progressive disease, resulted from the conglomeration of Ama and aggrevated Vata dosha which gets lodged in the small joints followed by large joints. If it is left untreated, may cause various complications in the form of Vataja diseases in which Raktadhatu kshaya (Anaemia) and Mutrakricchra (Urinary Tract Infection) are predominant. But it needs robust evidence to revalidate the same. Aim & Objective: To evaluate the association of Raktadhatu kshaya (Anaemia) and Mutrakricchra (Urinary Tract Infection) with Amavata (~Rheumatoid Arthritis). Materials & Methods: A case-control study was conducted from 18.04.2018 to 09.01.2020, containing 155 cases (patients of Amavata), and 163 controls (healthy volunteers), matching in age (between 18 to 50 years), and sex, selected from Jamnagar district.  Health Assessment proforma of TRISUTRA project CSIR-AYURGENOMICS for health assessment,  ACR, 1987 Criteria for RA diagnosis were used. Chi-square test was applied to find the association of Raktadhatu kshaya (Anaemia) and Mutrakricchra (Urinary Tract Infection) with Amavata whereas Unpaired or Mann-whitney U test was applied to compare the hematological parameters between case and control group. Results: Statistically significant differences were found in the mean values of haemoglobin, total leukocyte count, neutrophils, lymphocytes, eosinophils, monocytes, MCV, MCH, MCHC, PCV, total RBC count, and platelet count among both the groups. Microcytic and Dimorphic Anaemia were substantially higher (P<0.0001) in the Amavata patients than in the controls (χ2 value=24.814). The prevalence of UTI (presence of pus cells in the urine) was  found significantly more (P<0.0001) in Amavata patients than healthy individuals (χ2 value=45.347). Conclusion: Anaemia and Urinary tract infections are strongly associated with Amavata (~Rheumatoid Arthritis).