Purpose: To determine the importance of ganglion cell complex (GCC) analysis as a parameter for early diagnosis of glaucoma and for following glaucoma progression and to compare glaucoma progression with conventional visual field analysis using a different type of spectral-domain optical coherence tomography (SD-OCT).Materials and methods: Two hundred eyes including 68 normal eyes, 70 eyes with pre-perimetric glaucoma and 62 eyes with perimetric glaucoma were analyzed in this prospective study undertaken during Jan 2013 to Dec 2013 in a tertiary ophthalmology institute. Automated visual field examination was done to group the subjects in above three categories. The thicknesses of the GCC and retinal nerve fiber layer (pRNFL) were measured using Topcon model 2000 version 7.1 SD-OCT images and compared. The statistical analysis was carried out by z-test.Results: The average GCC was thickest in the normal group and the thickness decreased as the severity of glaucoma increased. The mean macular GCC at the start and end of the study in pre-perimetric (94.86 ± 8.31, 90.74 ± 8.46) and perimetric (82.48 ± 13.21, 79.80 ± 12.88) eyes was lower than those in normals (102.70 ± 7.19, 101.82 ± 7.42).Conclusion: Majority of the studies done on GCC analysis have used the Cirrus OCT (Zeiss). Our study has used the Topcon model 2000 version 7.1 to show that irrespective of the machine used, GCC analysis definitely plays an important role. To detect pre-perimetric glaucoma and may show progression earlier than pRNFL in pre-perimetric glaucoma.How to cite this article: Bhagat PR, Deshpande KV, Natu B. Utility of Ganglion Cell Complex Analysis in Early Diagnosis and Monitoring of Glaucoma using a Different Spectral Domain Optical Coherence Tomography. J Curr Glaucoma Pract 2014;8(3):101-106.

PURPOSE:To determine predisposing factors and to analyze visual outcomes after a dropped nucleus in vitreous originating during cataract surgery. Evaluation of management and outcome of patients undergoing pars plana vitrectomy. Evaluation of risk factors for poor visual outcomes, comparison of visual acuity following various types of IOL implantation. METHODS: 30 patients were prospectively reviewed having dropped nucleus or retained lens matter over a period of 11 months to determine the various associated factors and prognosis after pars plana vitrectomy and IOL implantation. Pre and Post-operative visual acuity, intraocular pressure, slit lamp examination, fundus examination by indirect ophthalmoscopy and ultrasound was done. Risk factors, Type of IOL, type of cataract surgery, complications and final visual outcomes were analyzed. All patients underwent 21 G pars plana vitrectomy and lens fragments were removed with phacofragmentome, vitrectomy cutter or delivered through limbus. RESULTS: 30 eyes of consecutive patients were studied. There were 20(66.66%) males and 10(33.33%) females. Associated risk factors found were 2(6.66%) PEX, 1(3.33%) subluxated lens. The BCVA after 11 months of PPV was found to be >6/12 in 20(66.6%) and <6/12 in 10(33.4%). Visual Rehabilitation was done with PCIOL in 22(73.33%), ACIOL in 4(13.33%), SFIOL in 4(13.33%). Poor visual outcome following PPV was attributed to RD in 2(6.7%), CME 1(3.3%), raised IOP 9(29.9%) [8(26.6% before and 1(3.3%) After PPV]. Rise of IOP was found in 8(26.60%) before PPV and 1(3.33%) after PPV.

To pre-operatively stage macular hole based on OCT and to calculate Macular Hole Index and Hole Form Factor. To determine post-operative visual outcome and macular hole closure. METHODS: Prospectively reviewed 25 eyes of Macular Hole. All the patients with complain of diminution of vision and defective central field of vision were examined. Before and after surgery complete clinical examination and OCT was performed which included macular hole diameter at the level of RPE(base diameter) and at the minimal extent of hole(minimum diameter),Vertical Height, Horizontal Diameter, Left Arm Length, Right Arm Length ,Macular Hole Index and Hole Form Factor. 21 Gauge Pars Plana Vitrectomy with ILM peeling was performed in all patients. RESULTS: 25 eyes of 25 consecutive patients were studied. There were 14 (56%) men and 11(44%) women, with an average age of 60 years (50 to 75 years, median 60 years) Mean follow up time was 1 month. At 3 months 6 of 25 patients (24%) attained a visual acuity greater than or equal to 6/36. Patients of macular hole were found to be most in idiopathic (18/25, 72%) in nature .On OCT most of the macular hole in stage 3 and stage 4 were associated with subretinal fluid, epiretinal membrane.12% patients had Grade II,40% had Grade III, 48% had Grade IV Macular Hole.Negative co-relation was found between both the base and minimum diameterand post-operative visual acuity. Post-operative outcome is better in pateints with MHI >0.5, HFF>0.9.